Organoids from the Human Fetal and Adult Pancreas

Jeetindra R A Balak; Juri Juksar; Françoise Carlotti; Antonio Lo Nigro; Eelco J P de Koning

doi:10.1007/s11892-019-1261-z

Organoids from the Human Fetal and Adult Pancreas

Jeetindra R A Balak, Juri Juksar, Françoise Carlotti, Antonio Lo Nigro, Eelco J P de Koning

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

36 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue-derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.

RECENT FINDINGS: Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses. Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.

Original language	English
Pages (from-to)	160
Journal	Current Diabetes Reports
Volume	19
Issue number	12
DOIs	https://doi.org/10.1007/s11892-019-1261-z
Publication status	Published - 11 Dec 2019

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AU - Juksar, Juri

AU - Carlotti, Françoise

AU - Lo Nigro, Antonio

AU - de Koning, Eelco J P

PY - 2019/12/11

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AB - PURPOSE OF REVIEW: Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue-derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.RECENT FINDINGS: Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses. Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.

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JO - Current Diabetes Reports

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Organoids from the Human Fetal and Adult Pancreas

Abstract

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