Oxidized low-density lipoproteins as a novel risk factor and therapeutic target for ACM

Hoyee Tsui, Su Ji Han, Eva van Rooij

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease involving arrhythmia in young adults accompanied by structural changes at later stages. In this issue of EMBO Molecular Medicine, Sommariva et al (2021) identified a positive correlation between circulating levels of oxidized low-density lipoproteins (oxLDL) and ACM disease penetrance, which contributes to fibro-fatty cardiac remodeling via the oxLDL/CD36/PPARγ axis. These data identify oxidized low-density lipoproteins as a risk factor for ACM and uncover a novel therapeutic intervention option to block disease pathogenesis.

Original languageEnglish
Pages (from-to)e14789
JournalEMBO Molecular Medicine
Volume13
Issue number9
DOIs
Publication statusPublished - 07 Sep 2021

Keywords

  • Arrhythmias, Cardiac
  • Arrhythmogenic Right Ventricular Dysplasia
  • Humans
  • Lipoproteins, LDL
  • Risk Factors

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