TY - JOUR
T1 - Pathways of Unconventional Protein Secretion
AU - Rabouille, Catherine
N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.
PY - 2016/12/15
Y1 - 2016/12/15
N2 - Secretory proteins are conventionally transported through the endoplasmic reticulum to the Golgi and then to the plasma membrane where they are released into the extracellular space. However, numerous substrates also reach these destinations using unconventional pathways. Unconventional protein secretion (UPS) is complex and comprises cargos without a signal peptide or a transmembrane domain that can translocate across the plasma membrane, and cargos that reach the plasma membrane by bypassing the Golgi despite entering the endoplasmic reticulum (ER). With a few exceptions, unconventional secretion is largely triggered by stress. Here I review new results and concepts that are beginning to define these pathways.
AB - Secretory proteins are conventionally transported through the endoplasmic reticulum to the Golgi and then to the plasma membrane where they are released into the extracellular space. However, numerous substrates also reach these destinations using unconventional pathways. Unconventional protein secretion (UPS) is complex and comprises cargos without a signal peptide or a transmembrane domain that can translocate across the plasma membrane, and cargos that reach the plasma membrane by bypassing the Golgi despite entering the endoplasmic reticulum (ER). With a few exceptions, unconventional secretion is largely triggered by stress. Here I review new results and concepts that are beginning to define these pathways.
U2 - 10.1016/j.tcb.2016.11.007
DO - 10.1016/j.tcb.2016.11.007
M3 - Article
C2 - 27989656
SN - 0962-8924
JO - Trends in Cell Biology
JF - Trends in Cell Biology
ER -