Phialemoniopsis limonesiae sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman

D. Alvarez Martinez, C. Alberto, A. Riat, C. Schuhler, P. Valladares, B. Ninet, B. Kraak, P. W. Crous, L. W. Hou, L. Toutous Trellu

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Rare or opportunistic fungal infections are mostly described in immunosuppressed patients. We present a case of a cutaneous phaeohyphomycosis that developed on the dorsal foot in an immunosuppressed woman suffering from AIDS, caused by a novel Phialemoniopsis species. It clinically presented as an indurated violaceous plaque, surmounted by nodules exuding a sero-purulent discharge. A filamentous fungus was isolated from pus and cutaneous biopsy. ITS and LSU sequences phylogenetically resolved the fungus as an unknown species of Phialemoniopsis, which is an unresolved family within Sordariomycetes. In this study we describe the new species as Phialemoniopsis limonesiae, which clusters on a single branch clearly separated from its closest phylogenetic neighbours. This new strain showed low MIC to itraconazole, voriconazole and posaconazole.
Original languageEnglish
Pages (from-to)400-406
Number of pages7
JournalEmerging Microbes and Infections
Volume10
Issue number1
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Bioavailability itraconazole
  • deep cutaneous phaeohyphomycosis
  • immunosuppression
  • opportunistic fungal infections
  • a new taxon

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