Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity

Luise Woost; Pierre-Louis Bazin; Marco Taubert; Robert Trampel; Christine L Tardif; Alexander Garthe; Gerd Kempermann; Ulrich Renner; Günter Stalla; Derek V M Ott; Viola Rjosk; Hellmuth Obrig; Arno Villringer; Elisabeth Roggenhofer; Tilmann A Klein

doi:10.1038/s41598-018-19993-9

Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity

Luise Woost, Pierre-Louis Bazin, Marco Taubert, Robert Trampel, Christine L Tardif, Alexander Garthe, Gerd Kempermann, Ulrich Renner, Günter Stalla, Derek V M Ott, Viola Rjosk, Hellmuth Obrig, Arno Villringer, Elisabeth Roggenhofer, Tilmann A Klein

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

Physical exercise has been suggested to improve cognitive performance through various neurobiological mechanisms, mediated by growth factors such as BDNF, IGF-I, and VEGF. Moreover, animal research has demonstrated that combined physical and cognitive stimulation leads to increased adult neurogenesis as compared to either experimental condition alone. In the present study, we therefore investigated whether a sequential combination of physical and spatial training in young, healthy adults elicits an additive effect on training and transfer gains. To this end, we compared the effects of (i) eight 20-minute sessions of cycling, (ii) sixteen 30-minute sessions of spatial training, (iii) a combination of both, and included (iv) a passive control cohort. We assessed longitudinal changes in cognitive performance, growth factor levels, and T1relaxation of hippocampal subfields (acquired with 7 T MRI). While substantial physical and spatial training gains were elicited in all trained groups, longitudinal transfer changes did not differ between these groups. Notably, we found no evidence for an additive effect of sequential physical and spatial training. These results challenge the extrapolation from the findings reported in animals to young, healthy adults.

Original language	English
Article number	4239
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-19993-9
Publication status	Published - 2018

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Journal Article

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Woost, L., Bazin, P.-L., Taubert, M., Trampel, R., Tardif, C. L., Garthe, A., Kempermann, G., Renner, U., Stalla, G., Ott, D. V. M., Rjosk, V., Obrig, H., Villringer, A., Roggenhofer, E., & Klein, T. A. (2018). Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity. Scientific Reports, 8(1), Article 4239. https://doi.org/10.1038/s41598-018-19993-9

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title = "Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity",

abstract = "Physical exercise has been suggested to improve cognitive performance through various neurobiological mechanisms, mediated by growth factors such as BDNF, IGF-I, and VEGF. Moreover, animal research has demonstrated that combined physical and cognitive stimulation leads to increased adult neurogenesis as compared to either experimental condition alone. In the present study, we therefore investigated whether a sequential combination of physical and spatial training in young, healthy adults elicits an additive effect on training and transfer gains. To this end, we compared the effects of (i) eight 20-minute sessions of cycling, (ii) sixteen 30-minute sessions of spatial training, (iii) a combination of both, and included (iv) a passive control cohort. We assessed longitudinal changes in cognitive performance, growth factor levels, and T1relaxation of hippocampal subfields (acquired with 7 T MRI). While substantial physical and spatial training gains were elicited in all trained groups, longitudinal transfer changes did not differ between these groups. Notably, we found no evidence for an additive effect of sequential physical and spatial training. These results challenge the extrapolation from the findings reported in animals to young, healthy adults.",

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author = "Luise Woost and Pierre-Louis Bazin and Marco Taubert and Robert Trampel and Tardif, {Christine L} and Alexander Garthe and Gerd Kempermann and Ulrich Renner and G{\"u}nter Stalla and Ott, {Derek V M} and Viola Rjosk and Hellmuth Obrig and Arno Villringer and Elisabeth Roggenhofer and Klein, {Tilmann A}",

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Woost, L, Bazin, P-L, Taubert, M, Trampel, R, Tardif, CL, Garthe, A, Kempermann, G, Renner, U, Stalla, G, Ott, DVM, Rjosk, V, Obrig, H, Villringer, A, Roggenhofer, E & Klein, TA 2018, 'Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity', Scientific Reports, vol. 8, no. 1, 4239. https://doi.org/10.1038/s41598-018-19993-9

TY - JOUR

T1 - Physical Exercise and Spatial Training

T2 - A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity

AU - Woost, Luise

AU - Bazin, Pierre-Louis

AU - Taubert, Marco

AU - Trampel, Robert

AU - Tardif, Christine L

AU - Garthe, Alexander

AU - Kempermann, Gerd

AU - Renner, Ulrich

AU - Stalla, Günter

AU - Ott, Derek V M

AU - Rjosk, Viola

AU - Obrig, Hellmuth

AU - Villringer, Arno

AU - Roggenhofer, Elisabeth

AU - Klein, Tilmann A

PY - 2018

Y1 - 2018

N2 - Physical exercise has been suggested to improve cognitive performance through various neurobiological mechanisms, mediated by growth factors such as BDNF, IGF-I, and VEGF. Moreover, animal research has demonstrated that combined physical and cognitive stimulation leads to increased adult neurogenesis as compared to either experimental condition alone. In the present study, we therefore investigated whether a sequential combination of physical and spatial training in young, healthy adults elicits an additive effect on training and transfer gains. To this end, we compared the effects of (i) eight 20-minute sessions of cycling, (ii) sixteen 30-minute sessions of spatial training, (iii) a combination of both, and included (iv) a passive control cohort. We assessed longitudinal changes in cognitive performance, growth factor levels, and T1relaxation of hippocampal subfields (acquired with 7 T MRI). While substantial physical and spatial training gains were elicited in all trained groups, longitudinal transfer changes did not differ between these groups. Notably, we found no evidence for an additive effect of sequential physical and spatial training. These results challenge the extrapolation from the findings reported in animals to young, healthy adults.

AB - Physical exercise has been suggested to improve cognitive performance through various neurobiological mechanisms, mediated by growth factors such as BDNF, IGF-I, and VEGF. Moreover, animal research has demonstrated that combined physical and cognitive stimulation leads to increased adult neurogenesis as compared to either experimental condition alone. In the present study, we therefore investigated whether a sequential combination of physical and spatial training in young, healthy adults elicits an additive effect on training and transfer gains. To this end, we compared the effects of (i) eight 20-minute sessions of cycling, (ii) sixteen 30-minute sessions of spatial training, (iii) a combination of both, and included (iv) a passive control cohort. We assessed longitudinal changes in cognitive performance, growth factor levels, and T1relaxation of hippocampal subfields (acquired with 7 T MRI). While substantial physical and spatial training gains were elicited in all trained groups, longitudinal transfer changes did not differ between these groups. Notably, we found no evidence for an additive effect of sequential physical and spatial training. These results challenge the extrapolation from the findings reported in animals to young, healthy adults.

KW - Journal Article

U2 - 10.1038/s41598-018-19993-9

DO - 10.1038/s41598-018-19993-9

M3 - Article

C2 - 29523857

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 4239

ER -

Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity

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