TY - JOUR
T1 - Plasticity mechanisms of genetically distinct Purkinje cells
AU - Voerman, Stijn
AU - Broersen, Robin
AU - Swagemakers, Sigrid M A
AU - De Zeeuw, Chris I
AU - van der Spek, Peter J
N1 - © 2024 The Authors. BioEssays published by Wiley Periodicals LLC.
PY - 2024/5/2
Y1 - 2024/5/2
N2 - Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.
AB - Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.
U2 - 10.1002/bies.202400008
DO - 10.1002/bies.202400008
M3 - Article
C2 - 38697917
SN - 0265-9247
VL - 46
SP - e2400008
JO - BioEssays
JF - BioEssays
ER -