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Population bottlenecks in multicomponent viruses: First forays into the uncharted territory of genome-formula drift. / Gutiérrez, Serafin (Corresponding author); Zwart, Mark.

In: Current Opinion in Virology, Vol. 33, No. December, 2018, p. 184-190.

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Gutiérrez, Serafin ; Zwart, Mark. / Population bottlenecks in multicomponent viruses: First forays into the uncharted territory of genome-formula drift. In: Current Opinion in Virology. 2018 ; Vol. 33, No. December. pp. 184-190.

BibTeX

@article{31be4122d9174637a58ab7b7d283482e,
title = "Population bottlenecks in multicomponent viruses: First forays into the uncharted territory of genome-formula drift",
abstract = "Multicomponent viral systems face specific challenges when enduring population bottlenecks. These systems can lose coding information due to the lack of co-encapsidation of all the genetic information, at least in a proportion of the capsids in a population. Moreover, bottlenecks can also impact one of the main potential advantages of multicomponent systems: the regulation of gene expression through changes in gene copy frequencies at the population level. How these systems cope with population bottlenecks is far from being clear. Here, two non-exclusive scenarios are described. In the first scenario, population bottlenecks during host infection allow for the isolation of within-host populations with different gene frequencies, leaving the door opened for the selection of populations with adaptive gene frequencies. The second scenario postulates that viruses could influence bottleneck size, at least at certain steps of their life cycle, to limit random changes in gene frequencies. Examples of viral mechanism impacting bottleneck size at cell infection are available and, intriguingly, they can lead to either increases or reductions in bottleneck size. This situation opens the way for putative trade-offs on both gene frequencies and bottleneck sizes that could differ among multicomponent systems.",
keywords = "international",
author = "Serafin Guti{\'e}rrez and Mark Zwart",
note = "6606, ME; Data Archiving: no data review",
year = "2018",
doi = "10.1016/j.coviro.2018.09.001",
language = "English",
volume = "33",
pages = "184--190",
journal = "Current Opinion in Virology",
issn = "1879-6257",
publisher = "Elsevier",
number = "December",

}

RIS

TY - JOUR

T1 - Population bottlenecks in multicomponent viruses: First forays into the uncharted territory of genome-formula drift

AU - Gutiérrez, Serafin

AU - Zwart, Mark

N1 - 6606, ME; Data Archiving: no data review

PY - 2018

Y1 - 2018

N2 - Multicomponent viral systems face specific challenges when enduring population bottlenecks. These systems can lose coding information due to the lack of co-encapsidation of all the genetic information, at least in a proportion of the capsids in a population. Moreover, bottlenecks can also impact one of the main potential advantages of multicomponent systems: the regulation of gene expression through changes in gene copy frequencies at the population level. How these systems cope with population bottlenecks is far from being clear. Here, two non-exclusive scenarios are described. In the first scenario, population bottlenecks during host infection allow for the isolation of within-host populations with different gene frequencies, leaving the door opened for the selection of populations with adaptive gene frequencies. The second scenario postulates that viruses could influence bottleneck size, at least at certain steps of their life cycle, to limit random changes in gene frequencies. Examples of viral mechanism impacting bottleneck size at cell infection are available and, intriguingly, they can lead to either increases or reductions in bottleneck size. This situation opens the way for putative trade-offs on both gene frequencies and bottleneck sizes that could differ among multicomponent systems.

AB - Multicomponent viral systems face specific challenges when enduring population bottlenecks. These systems can lose coding information due to the lack of co-encapsidation of all the genetic information, at least in a proportion of the capsids in a population. Moreover, bottlenecks can also impact one of the main potential advantages of multicomponent systems: the regulation of gene expression through changes in gene copy frequencies at the population level. How these systems cope with population bottlenecks is far from being clear. Here, two non-exclusive scenarios are described. In the first scenario, population bottlenecks during host infection allow for the isolation of within-host populations with different gene frequencies, leaving the door opened for the selection of populations with adaptive gene frequencies. The second scenario postulates that viruses could influence bottleneck size, at least at certain steps of their life cycle, to limit random changes in gene frequencies. Examples of viral mechanism impacting bottleneck size at cell infection are available and, intriguingly, they can lead to either increases or reductions in bottleneck size. This situation opens the way for putative trade-offs on both gene frequencies and bottleneck sizes that could differ among multicomponent systems.

KW - international

U2 - 10.1016/j.coviro.2018.09.001

DO - 10.1016/j.coviro.2018.09.001

M3 - Article

VL - 33

SP - 184

EP - 190

JO - Current Opinion in Virology

JF - Current Opinion in Virology

SN - 1879-6257

IS - December

ER -

ID: 8241392