Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

Alida Fe Talento; Katie Dunne; Niamh Murphy; Brian O'Connell; Grace Chan; Eimear Ann Joyce; Ferry Hagen; Jacques F Meis; Ruairi Fahy; Larry Bacon; Elisabeth Vandenberge; Thomas R Rogers

doi:10.1111/myc.12770

Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

Alida Fe Talento, Katie Dunne, Niamh Murphy, Brian O'Connell, Grace Chan, Eimear Ann Joyce, Ferry Hagen, Jacques F Meis, Ruairi Fahy, Larry Bacon, Elisabeth Vandenberge, Thomas R Rogers

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

9 Citations (Scopus)

Abstract

Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.

Original language	English
Pages (from-to)	570-575
Number of pages	6
Journal	Mycoses
Volume	61
Issue number	8
DOIs	https://doi.org/10.1111/myc.12770
Publication status	Published - Aug 2018

Keywords

Antifungal Agents/pharmacology
Aspergillus fumigatus/drug effects
Drug Resistance, Fungal
Humans
Influenza, Human/complications
Invasive Pulmonary Aspergillosis/diagnosis
Male
Middle Aged
Stem Cell Transplantation/adverse effects
Transplantation, Homologous/adverse effects
Triazoles/pharmacology

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10.1111/myc.12770

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title = "Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation",

abstract = "Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.",

keywords = "Antifungal Agents/pharmacology, Aspergillus fumigatus/drug effects, Drug Resistance, Fungal, Humans, Influenza, Human/complications, Invasive Pulmonary Aspergillosis/diagnosis, Male, Middle Aged, Stem Cell Transplantation/adverse effects, Transplantation, Homologous/adverse effects, Triazoles/pharmacology",

author = "Talento, {Alida Fe} and Katie Dunne and Niamh Murphy and Brian O'Connell and Grace Chan and Joyce, {Eimear Ann} and Ferry Hagen and Meis, {Jacques F} and Ruairi Fahy and Larry Bacon and Elisabeth Vandenberge and Rogers, {Thomas R}",

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year = "2018",

month = aug,

doi = "10.1111/myc.12770",

language = "English",

volume = "61",

pages = "570--575",

journal = "Mycoses",

issn = "0933-7407",

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TY - JOUR

T1 - Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

AU - Talento, Alida Fe

AU - Dunne, Katie

AU - Murphy, Niamh

AU - O'Connell, Brian

AU - Chan, Grace

AU - Joyce, Eimear Ann

AU - Hagen, Ferry

AU - Meis, Jacques F

AU - Fahy, Ruairi

AU - Bacon, Larry

AU - Vandenberge, Elisabeth

AU - Rogers, Thomas R

PY - 2018/8

Y1 - 2018/8

N2 - Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.

AB - Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.

KW - Antifungal Agents/pharmacology

KW - Aspergillus fumigatus/drug effects

KW - Drug Resistance, Fungal

KW - Humans

KW - Influenza, Human/complications

KW - Invasive Pulmonary Aspergillosis/diagnosis

KW - Male

KW - Middle Aged

KW - Stem Cell Transplantation/adverse effects

KW - Transplantation, Homologous/adverse effects

KW - Triazoles/pharmacology

U2 - 10.1111/myc.12770

DO - 10.1111/myc.12770

M3 - Article

C2 - 29570855

SN - 0933-7407

VL - 61

SP - 570

EP - 575

JO - Mycoses

JF - Mycoses

IS - 8

ER -

Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

Abstract

Keywords

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