Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

Alida Fe Talento, Katie Dunne, Niamh Murphy, Brian O'Connell, Grace Chan, Eimear Ann Joyce, Ferry Hagen, Jacques F Meis, Ruairi Fahy, Larry Bacon, Elisabeth Vandenberge, Thomas R Rogers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.

Original languageEnglish
Pages (from-to)570-575
Number of pages6
JournalMycoses
Volume61
Issue number8
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Antifungal Agents/pharmacology
  • Aspergillus fumigatus/drug effects
  • Drug Resistance, Fungal
  • Humans
  • Influenza, Human/complications
  • Invasive Pulmonary Aspergillosis/diagnosis
  • Male
  • Middle Aged
  • Stem Cell Transplantation/adverse effects
  • Transplantation, Homologous/adverse effects
  • Triazoles/pharmacology

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