Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species

Mahdi Abastabar, Abdullah M.S. Al-Hatmi, Mohammad Vafaei Moghaddam, G. Sybren De Hoog, Iman Haghani, Seyed Reza Aghili, Tahereh Shokohi, Mohammad Taghi Hedayati, Roshanak Daie Ghazvini, Reza Kachuei, Ali Rezaei-Matehkolaei, Koichi Makimura, Jacques F. Meis, Hamid Badalia

Research output: Chapter in book/volumeChapterScientificpeer-review

Abstract

Copyright © 2018 American Society for Microbiology. All Rights Reserved. A collection of clinical (n 47) and environmental (n 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 g/ml, respectively, compared with 0.51 g/ml for micafungin, 0.85 g/ml for efinaconazole, 1.12 g/ml for natamycin, 1.18 g/ml for anidulafungin, 1.31 g/ml for voriconazole, 1.35 g/ml for caspofungin, 1.9 g/ml for amphotericin B, and 4.08 g/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species.
Original languageEnglish
Title of host publicationAntimicrobial Agents and Chemotherapy
PublisherAmerican Society for Microbiology
ISBN (Print)0066-4804
DOIs
Publication statusPublished - 01 May 2018

Publication series

NameAntimicrobial Agents and Chemotherapy
Volume62

Keywords

  • Fusarium species
  • Intrinsic resistance
  • Lanoconazole
  • Luliconazole

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    Abastabar, M., Al-Hatmi, A. M. S., Moghaddam, M. V., De Hoog, G. S., Haghani, I., Aghili, S. R., Shokohi, T., Hedayati, M. T., Ghazvini, R. D., Kachuei, R., Rezaei-Matehkolaei, A., Makimura, K., Meis, J. F., & Badalia, H. (2018). Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species. In Antimicrobial Agents and Chemotherapy (Antimicrobial Agents and Chemotherapy; Vol. 62). American Society for Microbiology. https://doi.org/10.1128/AAC.00009-18