Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum

Aleksandra Maruszak; Edina Silajdžić; Hyunah Lee; Tytus Murphy; Benjamine Liu; Liu Shi; Chiara de Lucia; Abdel Douiri; Evgenia Salta; Alejo J Nevado; Charlotte E Teunissen; Pieter J Visser; Jack Price; Henrik Zetterberg; Simon Lovestone; Sandrine Thuret

doi:10.1093/brain/awac472

Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum

Aleksandra Maruszak, Edina Silajdžić, Hyunah Lee, Tytus Murphy, Benjamine Liu, Liu Shi, Chiara de Lucia, Abdel Douiri, Evgenia Salta, Alejo J Nevado, Charlotte E Teunissen, Pieter J Visser, Jack Price, Henrik Zetterberg, Simon Lovestone, Sandrine Thuret

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Abstract

Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer's disease. As hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurogenesis is affected by the systemic milieu could serve as an early biomarker for Alzheimer's disease progression. Here, we used an in vitro assay to model the impact of systemic environment on hippocampal neurogenesis. A human hippocampal progenitor cell line was treated with longitudinal serum samples from individuals with mild cognitive impairment, who either progressed to Alzheimer's disease or remained cognitively stable. Mild cognitive impairment to Alzheimer's disease progression was characterized most prominently with decreased proliferation, increased cell death and increased neurogenesis. A subset of 'baseline' cellular readouts together with education level were able to predict Alzheimer's disease progression. The assay could provide a powerful platform for early prognosis, monitoring disease progression and further mechanistic studies.

Original language	English
Pages (from-to)	2045-2058
Journal	Brain
Volume	146
DOIs	https://doi.org/10.1093/brain/awac472
Publication status	Published - 27 Jan 2023

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Maruszak, A., Silajdžić, E., Lee, H., Murphy, T., Liu, B., Shi, L., de Lucia, C., Douiri, A., Salta, E., Nevado, A. J., Teunissen, C. E., Visser, P. J., Price, J., Zetterberg, H., Lovestone, S., & Thuret, S. (2023). Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum. Brain, 146, 2045-2058. https://doi.org/10.1093/brain/awac472

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title = "Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum",

abstract = "Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer's disease. As hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurogenesis is affected by the systemic milieu could serve as an early biomarker for Alzheimer's disease progression. Here, we used an in vitro assay to model the impact of systemic environment on hippocampal neurogenesis. A human hippocampal progenitor cell line was treated with longitudinal serum samples from individuals with mild cognitive impairment, who either progressed to Alzheimer's disease or remained cognitively stable. Mild cognitive impairment to Alzheimer's disease progression was characterized most prominently with decreased proliferation, increased cell death and increased neurogenesis. A subset of 'baseline' cellular readouts together with education level were able to predict Alzheimer's disease progression. The assay could provide a powerful platform for early prognosis, monitoring disease progression and further mechanistic studies.",

author = "Aleksandra Maruszak and Edina Silajd{\v z}i{\'c} and Hyunah Lee and Tytus Murphy and Benjamine Liu and Liu Shi and {de Lucia}, Chiara and Abdel Douiri and Evgenia Salta and Nevado, {Alejo J} and Teunissen, {Charlotte E} and Visser, {Pieter J} and Jack Price and Henrik Zetterberg and Simon Lovestone and Sandrine Thuret",

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AU - Maruszak, Aleksandra

AU - Silajdžić, Edina

AU - Lee, Hyunah

AU - Murphy, Tytus

AU - Liu, Benjamine

AU - Shi, Liu

AU - de Lucia, Chiara

AU - Douiri, Abdel

AU - Salta, Evgenia

AU - Nevado, Alejo J

AU - Teunissen, Charlotte E

AU - Visser, Pieter J

AU - Price, Jack

AU - Zetterberg, Henrik

AU - Lovestone, Simon

AU - Thuret, Sandrine

PY - 2023/1/27

Y1 - 2023/1/27

N2 - Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer's disease. As hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurogenesis is affected by the systemic milieu could serve as an early biomarker for Alzheimer's disease progression. Here, we used an in vitro assay to model the impact of systemic environment on hippocampal neurogenesis. A human hippocampal progenitor cell line was treated with longitudinal serum samples from individuals with mild cognitive impairment, who either progressed to Alzheimer's disease or remained cognitively stable. Mild cognitive impairment to Alzheimer's disease progression was characterized most prominently with decreased proliferation, increased cell death and increased neurogenesis. A subset of 'baseline' cellular readouts together with education level were able to predict Alzheimer's disease progression. The assay could provide a powerful platform for early prognosis, monitoring disease progression and further mechanistic studies.

AB - Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer's disease. As hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurogenesis is affected by the systemic milieu could serve as an early biomarker for Alzheimer's disease progression. Here, we used an in vitro assay to model the impact of systemic environment on hippocampal neurogenesis. A human hippocampal progenitor cell line was treated with longitudinal serum samples from individuals with mild cognitive impairment, who either progressed to Alzheimer's disease or remained cognitively stable. Mild cognitive impairment to Alzheimer's disease progression was characterized most prominently with decreased proliferation, increased cell death and increased neurogenesis. A subset of 'baseline' cellular readouts together with education level were able to predict Alzheimer's disease progression. The assay could provide a powerful platform for early prognosis, monitoring disease progression and further mechanistic studies.

U2 - 10.1093/brain/awac472

DO - 10.1093/brain/awac472

M3 - Article

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SN - 0006-8950

VL - 146

SP - 2045

EP - 2058

JO - Brain

JF - Brain

ER -

Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum

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