Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results

Frédéric Grouiller, João Jorge, Francesca Pittau, W. Van der Zwaag, Giannina Rita Iannotti, Christoph Martin Michel, Serge Vulliémoz, Maria Isabel Vargas, François Lazeyras

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

OBJECTIVES: The aim of this study was to demonstrate that eloquent cortex and epileptic-related hemodynamic changes can be safely and reliably detected using simultaneous electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) recordings at ultra-high field (UHF) for clinical evaluation of patients with epilepsy.

MATERIALS AND METHODS: Simultaneous EEG-fMRI was acquired at 7 T using an optimized setup in nine patients with lesional epilepsy. According to the localization of the lesion, mapping of eloquent cortex (language and motor) was also performed in two patients.

RESULTS: Despite strong artifacts, efficient correction of intra-MRI EEG could be achieved with optimized artifact removal algorithms, allowing robust identification of interictal epileptiform discharges. Noise-sensitive topography-related analyses and electrical source localization were also performed successfully. Localization of epilepsy-related hemodynamic changes compatible with the lesion were detected in three patients and concordant with findings obtained at 3 T. Local loss of signal in specific regions, essentially due to B 1 inhomogeneities were found to depend on the geometric arrangement of EEG leads over the cap.

CONCLUSION: These results demonstrate that presurgical mapping of epileptic networks and eloquent cortex is both safe and feasible at UHF, with the benefits of greater spatial resolution and higher blood-oxygenation-level-dependent sensitivity compared with the more traditional field strength of 3 T.

Original languageEnglish
Pages (from-to)605-16
Number of pages12
JournalMagma
Volume29
Issue number3
DOIs
Publication statusPublished - Jun 2016

Keywords

  • Journal Article

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    Grouiller, F., Jorge, J., Pittau, F., Van der Zwaag, W., Iannotti, G. R., Michel, C. M., Vulliémoz, S., Vargas, M. I., & Lazeyras, F. (2016). Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results. Magma, 29(3), 605-16. https://doi.org/10.1007/s10334-016-0536-5