Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

Maria Alieva, Andreia S Margarido, Tamara Wieles, Erik R Abels, Burcin Colak, Carla Boquetale, Herke Jan Noordmans, Tom J Snijders, Marike L D Broekman, Jacco van Rheenen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

40 Citations (Scopus)

Abstract

Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients and intravital imaging of mice, we identify some of these negative aspects, including stimulation of proliferation and migration of non-resected tumor cells, and provide a strategy to prevent these adverse effects. By repeated high-resolution intravital microscopy, we show that biopsy-like injury in GBM induces migration and proliferation of tumor cells through chemokine (C-C motif) ligand 2 (CCL-2)-dependent recruitment of macrophages. Blocking macrophage recruitment or administrating dexamethasone, a commonly used glucocorticoid to prevent brain edema in GBM patients, suppressed the observed inflammatory response and subsequent tumor growth upon biopsy both in mice and in multifocal GBM patients. Taken together, our study suggests that inhibiting CCL-2-dependent recruitment of macrophages may further increase the clinical benefits from surgical and biopsy procedures.

Original languageEnglish
Pages (from-to)7529
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 08 Aug 2017

Keywords

  • Journal Article

Fingerprint

Dive into the research topics of 'Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior'. Together they form a unique fingerprint.

Cite this