Primed to perish: heightened mitochondrial priming explains hESC apoptosis sensitivity

N. Geijsen

doi:10.1016/j.stem.2013.09.011

Primed to perish: heightened mitochondrial priming explains hESC apoptosis sensitivity

N. Geijsen

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

3 Citations (Scopus)

Abstract

Human embryonic stem cells (hESCs) are hypersensitive to apoptotic stimuli, though the underlying mechanisms are poorly characterized. In this issue of Cell Stem Cell, Liu et al. (2013) report that mitochondria of human ESCs exist in an apoptosis-prone state, ready to act as cellular executioners upon detecting DNA damage.

Original language	English
Pages (from-to)	371-372
Journal	Cell Stem Cell
Volume	13
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2013.09.011
Publication status	Published - 2013

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10.1016/j.stem.2013.09.011

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title = "Primed to perish: heightened mitochondrial priming explains hESC apoptosis sensitivity",

abstract = "Human embryonic stem cells (hESCs) are hypersensitive to apoptotic stimuli, though the underlying mechanisms are poorly characterized. In this issue of Cell Stem Cell, Liu et al. (2013) report that mitochondria of human ESCs exist in an apoptosis-prone state, ready to act as cellular executioners upon detecting DNA damage.",

author = "N. Geijsen",

note = "Reporting year: 2013",

year = "2013",

doi = "10.1016/j.stem.2013.09.011",

language = "English",

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journal = "Cell Stem Cell",

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AU - Geijsen, N.

N1 - Reporting year: 2013

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AB - Human embryonic stem cells (hESCs) are hypersensitive to apoptotic stimuli, though the underlying mechanisms are poorly characterized. In this issue of Cell Stem Cell, Liu et al. (2013) report that mitochondria of human ESCs exist in an apoptosis-prone state, ready to act as cellular executioners upon detecting DNA damage.

U2 - 10.1016/j.stem.2013.09.011

DO - 10.1016/j.stem.2013.09.011

M3 - Article

SN - 1934-5909

VL - 13

SP - 371

EP - 372

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 4

ER -

Primed to perish: heightened mitochondrial priming explains hESC apoptosis sensitivity

Abstract

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