Progress and prospects in rat genetics: a community view.

T. Aitman; J.K. Critser; E. Cuppen; A. Dominiczak; X.M. Fernandez-Suarez; J. Flint; D. Gauguier; A.M. Geurts; M. Gould; P.C. Harris; R. Holmdahl; N. Hubner; Z. Izsvak; H. Jacob; T. Kuramoto; A.E. Kwitek; A. Marrone; T. Mashimo; C. Moreno; J. Mullins; L. Mullins; T. Olsson; M. Pravenec; L. Riley; K. Saar; T. Serikawa; J.D. Shull; C. Szpirer; S.N. Twigger; B. Voigt; K. Worley

doi:10.1038/ng.147

Progress and prospects in rat genetics: a community view.

T. Aitman, J.K. Critser, E. Cuppen, A. Dominiczak, X.M. Fernandez-Suarez, J. Flint, D. Gauguier, A.M. Geurts, M. Gould, P.C. Harris, R. Holmdahl, N. Hubner, Z. Izsvak, H. Jacob, T. Kuramoto, A.E. Kwitek, A. Marrone, T. Mashimo, C. Moreno, J. MullinsL. Mullins, T. Olsson, M. Pravenec, L. Riley, K. Saar, T. Serikawa, J.D. Shull, C. Szpirer, S.N. Twigger, B. Voigt, K. Worley

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

240 Citations (Scopus)

Abstract

The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.

Original language	English
Pages (from-to)	516-522
Journal	Nature Genetics
Volume	40
Issue number	5
DOIs	https://doi.org/10.1038/ng.147
Publication status	Published - 2008

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Aitman, T., Critser, J. K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X. M., Flint, J., Gauguier, D., Geurts, A. M., Gould, M., Harris, P. C., Holmdahl, R., Hubner, N., Izsvak, Z., Jacob, H., Kuramoto, T., Kwitek, A. E., Marrone, A., Mashimo, T., Moreno, C., ... Worley, K. (2008). Progress and prospects in rat genetics: a community view. Nature Genetics, 40(5), 516-522. https://doi.org/10.1038/ng.147

@article{143187c36f6c4686942ef8ec582b32c8,

title = "Progress and prospects in rat genetics: a community view.",

abstract = "The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.",

author = "T. Aitman and J.K. Critser and E. Cuppen and A. Dominiczak and X.M. Fernandez-Suarez and J. Flint and D. Gauguier and A.M. Geurts and M. Gould and P.C. Harris and R. Holmdahl and N. Hubner and Z. Izsvak and H. Jacob and T. Kuramoto and A.E. Kwitek and A. Marrone and T. Mashimo and C. Moreno and J. Mullins and L. Mullins and T. Olsson and M. Pravenec and L. Riley and K. Saar and T. Serikawa and J.D. Shull and C. Szpirer and S.N. Twigger and B. Voigt and K. Worley",

note = "Reporting year: 2008",

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doi = "10.1038/ng.147",

language = "English",

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pages = "516--522",

journal = "Nature Genetics",

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Aitman, T, Critser, JK, Cuppen, E, Dominiczak, A, Fernandez-Suarez, XM, Flint, J, Gauguier, D, Geurts, AM, Gould, M, Harris, PC, Holmdahl, R, Hubner, N, Izsvak, Z, Jacob, H, Kuramoto, T, Kwitek, AE, Marrone, A, Mashimo, T, Moreno, C, Mullins, J, Mullins, L, Olsson, T, Pravenec, M, Riley, L, Saar, K, Serikawa, T, Shull, JD, Szpirer, C, Twigger, SN, Voigt, B & Worley, K 2008, 'Progress and prospects in rat genetics: a community view.', Nature Genetics, vol. 40, no. 5, pp. 516-522. https://doi.org/10.1038/ng.147

TY - JOUR

T1 - Progress and prospects in rat genetics: a community view.

AU - Aitman, T.

AU - Critser, J.K.

AU - Cuppen, E.

AU - Dominiczak, A.

AU - Fernandez-Suarez, X.M.

AU - Flint, J.

AU - Gauguier, D.

AU - Geurts, A.M.

AU - Gould, M.

AU - Harris, P.C.

AU - Holmdahl, R.

AU - Hubner, N.

AU - Izsvak, Z.

AU - Jacob, H.

AU - Kuramoto, T.

AU - Kwitek, A.E.

AU - Marrone, A.

AU - Mashimo, T.

AU - Moreno, C.

AU - Mullins, J.

AU - Mullins, L.

AU - Olsson, T.

AU - Pravenec, M.

AU - Riley, L.

AU - Saar, K.

AU - Serikawa, T.

AU - Shull, J.D.

AU - Szpirer, C.

AU - Twigger, S.N.

AU - Voigt, B.

AU - Worley, K.

N1 - Reporting year: 2008

PY - 2008

Y1 - 2008

N2 - The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.

AB - The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.

U2 - 10.1038/ng.147

DO - 10.1038/ng.147

M3 - Article

SN - 1061-4036

VL - 40

SP - 516

EP - 522

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Progress and prospects in rat genetics: a community view.

Abstract

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