Promises and Challenges of Organoid-Guided Precision Medicine

Shree Bose, Hans Clevers, Xiling Shen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Organoids are self-organizing, expanding 3D cultures derived from stem cells. Using tissue derived from patients, these miniaturized models recapitulate various aspects of patient physiology and disease phenotypes including genetic profiles and drug sensitivities. As such, patient-derived organoid (PDO) platforms provide an unprecedented opportunity for improving preclinical drug discovery, clinical trial validation, and ultimately patient care. This article reviews the evolution and scope of organoid technology, highlights recent encouraging results using PDOs as potential patient "avatars" to predict drug response and outcomes, and discusses critical parameters for widespread clinical adoption. These include improvements in assay speed, reproducibility, standardization, and automation which are necessary to realize the translational potential of PDOs as clinical tools. The multiple entry points where PDOs may contribute valuable insights in drug discovery and lessen the risks associated with clinical trials are also discussed.

Original languageEnglish
Pages (from-to)1011-1026
Number of pages16
JournalMed (New York, N.Y.)
Volume2
Issue number9
DOIs
Publication statusPublished - 10 Sep 2021

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