Protein tyrosine phosphatases: regulatory mechanisms.

TY - JOUR

T1 - Protein tyrosine phosphatases: regulatory mechanisms.

AU - den Hertog, J.

AU - Ostman, A.

AU - Bohmer, F.D.

N1 - Reporting year: 2008

PY - 2008

Y1 - 2008

N2 - Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.

AB - Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.

U2 - 10.1111/j.1742-4658.2008.06247.x

DO - 10.1111/j.1742-4658.2008.06247.x

M3 - Article

SN - 1742-464X

VL - 275

SP - 831

EP - 847

JO - FEBS Journal

JF - FEBS Journal

IS - 5

ER -