Protein tyrosine phosphatases: regulatory mechanisms.

J. den Hertog, A. Ostman, F.D. Bohmer

Research output: Contribution to journal/periodicalArticleScientificpeer-review

98 Citations (Scopus)


Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.
Original languageEnglish
Pages (from-to)831-847
JournalFEBS Journal
Issue number5
Publication statusPublished - 2008


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