Protein tyrosine phosphatases: regulatory mechanisms.

J. den Hertog; A. Ostman; F.D. Bohmer

doi:10.1111/j.1742-4658.2008.06247.x

Protein tyrosine phosphatases: regulatory mechanisms.

J. den Hertog, A. Ostman, F.D. Bohmer

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

106 Citations (Scopus)

Abstract

Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.

Original language	English
Pages (from-to)	831-847
Journal	FEBS Journal
Volume	275
Issue number	5
DOIs	https://doi.org/10.1111/j.1742-4658.2008.06247.x
Publication status	Published - 2008

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title = "Protein tyrosine phosphatases: regulatory mechanisms.",

abstract = "Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.",

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AB - Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.

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DO - 10.1111/j.1742-4658.2008.06247.x

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EP - 847

JO - FEBS Journal

JF - FEBS Journal

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Protein tyrosine phosphatases: regulatory mechanisms.

Abstract

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