PRRT2-dependent dyskinesia: cerebellar, paroxysmal and persistent

TY - JOUR

T1 - PRRT2-dependent dyskinesia

T2 - cerebellar, paroxysmal and persistent

AU - Kros, Lieke

AU - De Zeeuw, Chris I

PY - 2018

Y1 - 2018

N2 - In an elegant publication in Cell Research, Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia. PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons, which in turn controls the activity patterns of Purkinje cells, the sole output of the cerebellar cortex.

AB - In an elegant publication in Cell Research, Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia. PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons, which in turn controls the activity patterns of Purkinje cells, the sole output of the cerebellar cortex.

KW - Journal Article

U2 - 10.1038/cr.2017.142

DO - 10.1038/cr.2017.142

M3 - Article

C2 - 29148542

SN - 1001-0602

VL - 28

SP - 3

EP - 4

JO - Cell Research

JF - Cell Research

ER -