PRRT2-dependent dyskinesia: cerebellar, paroxysmal and persistent

Lieke Kros, Chris I De Zeeuw

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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In an elegant publication in Cell Research, Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia. PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons, which in turn controls the activity patterns of Purkinje cells, the sole output of the cerebellar cortex.

Original languageEnglish
Pages (from-to)3-4
JournalCell Research
Publication statusPublished - 2018


  • Journal Article

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