Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

W.H.G. Hol; J.A. Van Veen

doi:10.1023/A:1020557000707

Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

W.H.G. Hol, J.A. Van Veen

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]

Original language	English
Pages (from-to)	1763-1772
Journal	Journal of Chemical Ecology
Volume	28
Issue number	9
DOIs	https://doi.org/10.1023/A:1020557000707
Publication status	Published - 2002

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title = "Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth",

abstract = "We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]",

author = "W.H.G. Hol and {Van Veen}, J.A.",

note = "Reporting year: 2002 Metis note: 3078; CTE; TME ; TE; file:///L:/Endnotedatabases/NIOOPUB/pdfs/Pdfs2002/Hol_ea_3078.pdf",

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doi = "10.1023/A:1020557000707",

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T1 - Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

AU - Hol, W.H.G.

AU - Van Veen, J.A.

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N2 - We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]

AB - We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]

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DO - 10.1023/A:1020557000707

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SP - 1763

EP - 1772

JO - Journal of Chemical Ecology

JF - Journal of Chemical Ecology

IS - 9

ER -

Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

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