Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

W.H.G. Hol, J.A. Van Veen

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    75 Citations (Scopus)


    We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]
    Original languageEnglish
    Pages (from-to)1763-1772
    JournalJournal of Chemical Ecology
    Issue number9
    Publication statusPublished - 2002


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