Rapid adaptation of primate LGN neurons to drifting grating stimulation

Loïc Daumail; Brock M Carlson; Blake A Mitchell; Michele A Cox; Jacob A Westerberg; Cortez Johnson; Paul R Martin; Frank Tong; Alexander Maier; Kacie Dougherty

doi:10.1152/jn.00058.2022

Rapid adaptation of primate LGN neurons to drifting grating stimulation

Loïc Daumail, Brock M Carlson, Blake A Mitchell, Michele A Cox, Jacob A Westerberg, Cortez Johnson, Paul R Martin, Frank Tong, Alexander Maier, Kacie Dougherty

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

1 Citation (Scopus)

Abstract

The visual system needs to dynamically adapt to changing environments. Much is known about the adaptive effects of constant stimulation over prolonged periods of time. However, there are open questions regarding adaptation to stimuli that are changing over time, interrupted, or repeated. Feature-specific adaptation to repeating stimuli has been shown to occur as early as primary visual cortex (V1), but there is also evidence for more generalized, fatigue-like adaptation that might occur at an earlier stage of processing. Here, we show adaptation in the lateral geniculate nucleus (LGN) of awake, fixating monkeys following brief (1 s) exposure to repeated cycles of a 4 Hz drifting grating. We examined the relative change of each neuron's response across successive (repeated) grating cycles. We found that neurons from all cell classes (parvocellular, magnocellular, and koniocellular) showed significant adaptation. However, only magnocellular neurons showed adaptation when responses were averaged to a population response. In contrast to firing rates, response variability was largely unaffected. Lastly, adaptation was comparable between monocular and binocular stimulation, suggesting that rapid LGN adaptation is monocular in nature.

Original language	English
Pages (from-to)	1447-1467
Journal	Journal of Neurophysiology
Volume	129
DOIs	https://doi.org/10.1152/jn.00058.2022
Publication status	Published - May 2023

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title = "Rapid adaptation of primate LGN neurons to drifting grating stimulation",

abstract = "The visual system needs to dynamically adapt to changing environments. Much is known about the adaptive effects of constant stimulation over prolonged periods of time. However, there are open questions regarding adaptation to stimuli that are changing over time, interrupted, or repeated. Feature-specific adaptation to repeating stimuli has been shown to occur as early as primary visual cortex (V1), but there is also evidence for more generalized, fatigue-like adaptation that might occur at an earlier stage of processing. Here, we show adaptation in the lateral geniculate nucleus (LGN) of awake, fixating monkeys following brief (1 s) exposure to repeated cycles of a 4 Hz drifting grating. We examined the relative change of each neuron's response across successive (repeated) grating cycles. We found that neurons from all cell classes (parvocellular, magnocellular, and koniocellular) showed significant adaptation. However, only magnocellular neurons showed adaptation when responses were averaged to a population response. In contrast to firing rates, response variability was largely unaffected. Lastly, adaptation was comparable between monocular and binocular stimulation, suggesting that rapid LGN adaptation is monocular in nature.",

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doi = "10.1152/jn.00058.2022",

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T1 - Rapid adaptation of primate LGN neurons to drifting grating stimulation

AU - Daumail, Loïc

AU - Carlson, Brock M

AU - Mitchell, Blake A

AU - Cox, Michele A

AU - Westerberg, Jacob A

AU - Johnson, Cortez

AU - Martin, Paul R

AU - Tong, Frank

AU - Maier, Alexander

AU - Dougherty, Kacie

PY - 2023/5

Y1 - 2023/5

N2 - The visual system needs to dynamically adapt to changing environments. Much is known about the adaptive effects of constant stimulation over prolonged periods of time. However, there are open questions regarding adaptation to stimuli that are changing over time, interrupted, or repeated. Feature-specific adaptation to repeating stimuli has been shown to occur as early as primary visual cortex (V1), but there is also evidence for more generalized, fatigue-like adaptation that might occur at an earlier stage of processing. Here, we show adaptation in the lateral geniculate nucleus (LGN) of awake, fixating monkeys following brief (1 s) exposure to repeated cycles of a 4 Hz drifting grating. We examined the relative change of each neuron's response across successive (repeated) grating cycles. We found that neurons from all cell classes (parvocellular, magnocellular, and koniocellular) showed significant adaptation. However, only magnocellular neurons showed adaptation when responses were averaged to a population response. In contrast to firing rates, response variability was largely unaffected. Lastly, adaptation was comparable between monocular and binocular stimulation, suggesting that rapid LGN adaptation is monocular in nature.

AB - The visual system needs to dynamically adapt to changing environments. Much is known about the adaptive effects of constant stimulation over prolonged periods of time. However, there are open questions regarding adaptation to stimuli that are changing over time, interrupted, or repeated. Feature-specific adaptation to repeating stimuli has been shown to occur as early as primary visual cortex (V1), but there is also evidence for more generalized, fatigue-like adaptation that might occur at an earlier stage of processing. Here, we show adaptation in the lateral geniculate nucleus (LGN) of awake, fixating monkeys following brief (1 s) exposure to repeated cycles of a 4 Hz drifting grating. We examined the relative change of each neuron's response across successive (repeated) grating cycles. We found that neurons from all cell classes (parvocellular, magnocellular, and koniocellular) showed significant adaptation. However, only magnocellular neurons showed adaptation when responses were averaged to a population response. In contrast to firing rates, response variability was largely unaffected. Lastly, adaptation was comparable between monocular and binocular stimulation, suggesting that rapid LGN adaptation is monocular in nature.

U2 - 10.1152/jn.00058.2022

DO - 10.1152/jn.00058.2022

M3 - Article

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SN - 0022-3077

VL - 129

SP - 1447

EP - 1467

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

ER -

Rapid adaptation of primate LGN neurons to drifting grating stimulation

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