Rat genetics: the next episode

B.M. Smits; E. Cuppen

doi:10.1016/j.tig.2006.02.009

Rat genetics: the next episode

B.M. Smits, E. Cuppen

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human disease have been identified in a wide range of rat inbred lines over the past few decades. With the complete rat genome available, it is now time for the next stage in rat genetic research: the identification and causal confirmation of underlying polymorphisms and genes. Recent developments in single nucleotide polymorphism-based genetic markers and technologies to manipulate the rat genome will undoubtedly be important tools in this next episode.

Original language	English
Pages (from-to)	232-240
Journal	Trends in Genetics
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.tig.2006.02.009
Publication status	Published - 2006

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title = "Rat genetics: the next episode",

abstract = "More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human disease have been identified in a wide range of rat inbred lines over the past few decades. With the complete rat genome available, it is now time for the next stage in rat genetic research: the identification and causal confirmation of underlying polymorphisms and genes. Recent developments in single nucleotide polymorphism-based genetic markers and technologies to manipulate the rat genome will undoubtedly be important tools in this next episode.",

author = "B.M. Smits and E. Cuppen",

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AB - More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human disease have been identified in a wide range of rat inbred lines over the past few decades. With the complete rat genome available, it is now time for the next stage in rat genetic research: the identification and causal confirmation of underlying polymorphisms and genes. Recent developments in single nucleotide polymorphism-based genetic markers and technologies to manipulate the rat genome will undoubtedly be important tools in this next episode.

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DO - 10.1016/j.tig.2006.02.009

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JO - Trends in Genetics

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Rat genetics: the next episode

Abstract

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