Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

Ferry Hagen; Kantarawee Khayhan; Bart Theelen; Anna Kolecka; Itzhack Polacheck; Edward Sionov; Rama Falk; Sittiporn Parnmen; H Thorsten Lumbsch; Teun Boekhout

doi:10.1016/j.fgb.2015.02.009

Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

Ferry Hagen, Kantarawee Khayhan, Bart Theelen, Anna Kolecka, Itzhack Polacheck, Edward Sionov, Rama Falk, Sittiporn Parnmen, H Thorsten Lumbsch, Teun Boekhout

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

547 Citations (Scopus)

Abstract

Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus neoformans species complex. Genealogical concordance, coalescence-based, and species tree approaches supported the presence of distinct and concordant lineages within the complex. Consequently, we propose to recognize the current C. neoformans var. grubii and C. neoformans var. neoformans as separate species, and five species within C. gattii. The type strain of C. neoformans CBS132 represents a serotype AD hybrid and is replaced. The newly delimited species differ in aspects of pathogenicity, prevalence for patient groups, as well as biochemical and physiological aspects, such as susceptibility to antifungals. MALDI-TOF mass spectrometry readily distinguishes the newly recognized species.

Original language	English
Pages (from-to)	16-48
Number of pages	33
Journal	Fungal Genetics and Biology
Volume	78
DOIs	https://doi.org/10.1016/j.fgb.2015.02.009
Publication status	Published - May 2015

Keywords

Cryptic species
Cryptococcus gattii
Cryptococcus neoformans
Yeast
Pathogen
Taxonomy

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10.1016/j.fgb.2015.02.009

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@article{294e2188760b4cfea17571acbce2077c,

title = "Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex",

abstract = "Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus neoformans species complex. Genealogical concordance, coalescence-based, and species tree approaches supported the presence of distinct and concordant lineages within the complex. Consequently, we propose to recognize the current C. neoformans var. grubii and C. neoformans var. neoformans as separate species, and five species within C. gattii. The type strain of C. neoformans CBS132 represents a serotype AD hybrid and is replaced. The newly delimited species differ in aspects of pathogenicity, prevalence for patient groups, as well as biochemical and physiological aspects, such as susceptibility to antifungals. MALDI-TOF mass spectrometry readily distinguishes the newly recognized species.",

keywords = "Cryptic species, Cryptococcus gattii, Cryptococcus neoformans, Yeast, Pathogen, Taxonomy",

author = "Ferry Hagen and Kantarawee Khayhan and Bart Theelen and Anna Kolecka and Itzhack Polacheck and Edward Sionov and Rama Falk and Sittiporn Parnmen and Lumbsch, {H Thorsten} and Teun Boekhout",

year = "2015",

month = may,

doi = "10.1016/j.fgb.2015.02.009",

language = "English",

volume = "78",

pages = "16--48",

journal = "Fungal Genetics and Biology",

issn = "1087-1845",

publisher = "Academic Press",

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T1 - Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

AU - Hagen, Ferry

AU - Khayhan, Kantarawee

AU - Theelen, Bart

AU - Kolecka, Anna

AU - Polacheck, Itzhack

AU - Sionov, Edward

AU - Falk, Rama

AU - Parnmen, Sittiporn

AU - Lumbsch, H Thorsten

AU - Boekhout, Teun

PY - 2015/5

Y1 - 2015/5

N2 - Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus neoformans species complex. Genealogical concordance, coalescence-based, and species tree approaches supported the presence of distinct and concordant lineages within the complex. Consequently, we propose to recognize the current C. neoformans var. grubii and C. neoformans var. neoformans as separate species, and five species within C. gattii. The type strain of C. neoformans CBS132 represents a serotype AD hybrid and is replaced. The newly delimited species differ in aspects of pathogenicity, prevalence for patient groups, as well as biochemical and physiological aspects, such as susceptibility to antifungals. MALDI-TOF mass spectrometry readily distinguishes the newly recognized species.

AB - Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus neoformans species complex. Genealogical concordance, coalescence-based, and species tree approaches supported the presence of distinct and concordant lineages within the complex. Consequently, we propose to recognize the current C. neoformans var. grubii and C. neoformans var. neoformans as separate species, and five species within C. gattii. The type strain of C. neoformans CBS132 represents a serotype AD hybrid and is replaced. The newly delimited species differ in aspects of pathogenicity, prevalence for patient groups, as well as biochemical and physiological aspects, such as susceptibility to antifungals. MALDI-TOF mass spectrometry readily distinguishes the newly recognized species.

KW - Cryptic species

KW - Cryptococcus gattii

KW - Cryptococcus neoformans

KW - Yeast

KW - Pathogen

KW - Taxonomy

U2 - 10.1016/j.fgb.2015.02.009

DO - 10.1016/j.fgb.2015.02.009

M3 - Article

C2 - 25721988

SN - 1087-1845

VL - 78

SP - 16

EP - 48

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

ER -

Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

Abstract

Keywords

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