Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Nelda Antonovaite; Steven V Beekmans; Elly M Hol; Wytse J Wadman; Davide Iannuzzi

doi:10.1038/s41598-018-31035-y

Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Nelda Antonovaite, Steven V Beekmans, Elly M Hol, Wytse J Wadman, Davide Iannuzzi

Netherlands Institute for Neuroscience (NIN)

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Abstract

The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of acute horizontal live mouse brain slices. Our results confirm the highly viscoelestic nature of brain tissue. We further show that the mechanical properties are non-uniform and at least related to differences in morphological composition. Interestingly, areas with higher nuclear density appear to be softer than areas with lower nuclear density.

Original language	English
Pages (from-to)	12517
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-31035-y
Publication status	Published - 2018

Keywords

Journal Article

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AU - Iannuzzi, Davide

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