Reparative inflammation takes charge of tissue regeneration

Michael Karin; Hans Clevers

doi:10.1038/nature17039

Reparative inflammation takes charge of tissue regeneration

Michael Karin, Hans Clevers

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

576 Citations (Scopus)

Abstract

Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.

Original language	English
Pages (from-to)	307-15
Number of pages	9
Journal	Nature
Volume	529
Issue number	7586
DOIs	https://doi.org/10.1038/nature17039
Publication status	Published - 21 Jan 2016

Keywords

Animals
Cytokines
Drosophila melanogaster
Humans
Inflammation
Microbiota
Regeneration
Signal Transduction
Therapeutics
Wound Healing

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10.1038/nature17039

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KW - Cytokines

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KW - Humans

KW - Inflammation

KW - Microbiota

KW - Regeneration

KW - Signal Transduction

KW - Therapeutics

KW - Wound Healing

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Reparative inflammation takes charge of tissue regeneration

Abstract

Keywords

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