RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling

C.M. Cruciat, C. Dolde, R.E. de Groot, B. Ohkawara, C. Reinhard, H.C. Korswagen, C. Niehrs

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-beta-catenin network, where it acts as a regulatory subunit of CK1epsilon: In a Wnt-dependent manner, DDX3 binds CK1epsilon and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt-beta-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families.
Original languageEnglish
Pages (from-to)1436-1441
JournalScience Magazine
Volume339
Issue number6126
DOIs
Publication statusPublished - 2013

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