Role of Unipolar Brush Cells in the Vestibulocerebellum

Rachel N. Koops*, Cathrin B. Canto, Bin Wu, Martijn Schonewille, Beerend H.J. Winkelman, Chris I. De Zeeuw

*Corresponding author for this work

Research output: Chapter in book/volumeChapterScientificpeer-review

2 Citations (Scopus)

Abstract

In all species, unipolar brush cells (UBCs) are most abundant in the vestibulocerebellum. Yet, the role of these excitatory interneurons in the cerebellar input stage during visual and vestibular stimulation remains elusive. Here, we review the main morphological and electrophysiological properties of UBCs in the vestibulocerebellum, and we highlight their potential role in the flocculus during the coordination of compensatory eye movements. We advocate that they are well designed to contribute to expansion coding in the temporal domain, while preserving the identity of sensory and/or oculomotor encoding, so as to facilitate the optimal acquisition of all possible components of movement kinematics.

Original languageEnglish
Title of host publicationEssentials of Cerebellum and Cerebellar Disorders
Subtitle of host publicationA Primer For Graduate Students, Second Edition
PublisherSpringer International Publishing AG
Pages243-258
Number of pages16
ISBN (Electronic)9783031150708
ISBN (Print)9783031150692
DOIs
Publication statusPublished - 01 Jan 2023

Keywords

  • Expansion coding
  • Gain control
  • Glutamate entrapment
  • Identity preservation
  • Neural integration
  • Phase control
  • Signal delay lines

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