Sailing with the Wnt: charting the Wnt processing and secretion route

TY - JOUR

T1 - Sailing with the Wnt: charting the Wnt processing and secretion route

AU - Lorenowicz, M.J.

AU - Korswagen, H.C.

N1 - Reporting year: 2009 Metis note: S0014-4827(09)00286-9

PY - 2009

Y1 - 2009

N2 - Wnt proteins are members of a highly conserved family of signalling molecules that play a central role in development and disease. During the past years, the different signalling pathways that are triggered by Wnt proteins have been studied in detail, but it is still largely unknown how a functional Wnt protein is produced and secreted. The recent finding that Wnt proteins are post-translationally modified and the discovery of the Wnt binding protein Wntless and its trafficking by the retromer complex show that Wnt secretion is a complex and highly regulated process. In this review, we will give an overview of the Wnt maturation and secretion pathway and discuss how this process may influence the spreading and signalling activity of Wnt.

AB - Wnt proteins are members of a highly conserved family of signalling molecules that play a central role in development and disease. During the past years, the different signalling pathways that are triggered by Wnt proteins have been studied in detail, but it is still largely unknown how a functional Wnt protein is produced and secreted. The recent finding that Wnt proteins are post-translationally modified and the discovery of the Wnt binding protein Wntless and its trafficking by the retromer complex show that Wnt secretion is a complex and highly regulated process. In this review, we will give an overview of the Wnt maturation and secretion pathway and discuss how this process may influence the spreading and signalling activity of Wnt.

U2 - 10.1016/j.yexcr.2009.06.015

DO - 10.1016/j.yexcr.2009.06.015

M3 - Article

SN - 0014-4827

VL - 315

SP - 2683

EP - 2689

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 16

ER -