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Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit. / Cohen, Charles C H; Popovic, Marko A; Klooster, Jan; Weil, Marie-Theres; Möbius, Wiebke; Nave, Klaus-Armin; Kole, Maarten H P.

In: Cell, 14.01.2020.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Harvard

APA

Cohen, C. C. H., Popovic, M. A., Klooster, J., Weil, M-T., Möbius, W., Nave, K-A., & Kole, M. H. P. (2020). Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit. Cell. https://doi.org/10.1016/j.cell.2019.11.039

Vancouver

Cohen CCH, Popovic MA, Klooster J, Weil M-T, Möbius W, Nave K-A et al. Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit. Cell. 2020 Jan 14. https://doi.org/10.1016/j.cell.2019.11.039

Author

Cohen, Charles C H ; Popovic, Marko A ; Klooster, Jan ; Weil, Marie-Theres ; Möbius, Wiebke ; Nave, Klaus-Armin ; Kole, Maarten H P. / Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit. In: Cell. 2020.

BibTeX

@article{24b9c43ea28f475fa5a1483a1b8ae90a,
title = "Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit",
abstract = "The propagation of electrical impulses along axons is highly accelerated by the myelin sheath and produces saltating or {"}jumping{"} action potentials across internodes, from one node of Ranvier to the next. The underlying electrical circuit, as well as the existence and role of submyelin conduction in saltatory conduction remain, however, elusive. Here, we made patch-clamp and high-speed voltage-calibrated optical recordings of potentials across the nodal and internodal axolemma of myelinated neocortical pyramidal axons combined with electron microscopy and experimentally constrained cable modeling. Our results reveal a nanoscale yet conductive periaxonal space, incompletely sealed at the paranodes, which separates the potentials across the low-capacitance myelin sheath and internodal axolemma. The emerging double-cable model reproduces the recorded evolution of voltage waveforms across nodes and internodes, including rapid nodal potentials traveling in advance of attenuated waves in the internodal axolemma, revealing a mechanism for saltation across time and space.",
author = "Cohen, {Charles C H} and Popovic, {Marko A} and Jan Klooster and Marie-Theres Weil and Wiebke M{\"o}bius and Klaus-Armin Nave and Kole, {Maarten H P}",
note = "Copyright {\circledC} 2019 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = "1",
day = "14",
doi = "10.1016/j.cell.2019.11.039",
language = "English",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",

}

RIS

TY - JOUR

T1 - Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit

AU - Cohen, Charles C H

AU - Popovic, Marko A

AU - Klooster, Jan

AU - Weil, Marie-Theres

AU - Möbius, Wiebke

AU - Nave, Klaus-Armin

AU - Kole, Maarten H P

N1 - Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2020/1/14

Y1 - 2020/1/14

N2 - The propagation of electrical impulses along axons is highly accelerated by the myelin sheath and produces saltating or "jumping" action potentials across internodes, from one node of Ranvier to the next. The underlying electrical circuit, as well as the existence and role of submyelin conduction in saltatory conduction remain, however, elusive. Here, we made patch-clamp and high-speed voltage-calibrated optical recordings of potentials across the nodal and internodal axolemma of myelinated neocortical pyramidal axons combined with electron microscopy and experimentally constrained cable modeling. Our results reveal a nanoscale yet conductive periaxonal space, incompletely sealed at the paranodes, which separates the potentials across the low-capacitance myelin sheath and internodal axolemma. The emerging double-cable model reproduces the recorded evolution of voltage waveforms across nodes and internodes, including rapid nodal potentials traveling in advance of attenuated waves in the internodal axolemma, revealing a mechanism for saltation across time and space.

AB - The propagation of electrical impulses along axons is highly accelerated by the myelin sheath and produces saltating or "jumping" action potentials across internodes, from one node of Ranvier to the next. The underlying electrical circuit, as well as the existence and role of submyelin conduction in saltatory conduction remain, however, elusive. Here, we made patch-clamp and high-speed voltage-calibrated optical recordings of potentials across the nodal and internodal axolemma of myelinated neocortical pyramidal axons combined with electron microscopy and experimentally constrained cable modeling. Our results reveal a nanoscale yet conductive periaxonal space, incompletely sealed at the paranodes, which separates the potentials across the low-capacitance myelin sheath and internodal axolemma. The emerging double-cable model reproduces the recorded evolution of voltage waveforms across nodes and internodes, including rapid nodal potentials traveling in advance of attenuated waves in the internodal axolemma, revealing a mechanism for saltation across time and space.

U2 - 10.1016/j.cell.2019.11.039

DO - 10.1016/j.cell.2019.11.039

M3 - Article

JO - Cell

JF - Cell

SN - 0092-8674

ER -

ID: 12789463