Scedosporium and Lomentospora: An updated overview of underrated opportunists

Andoni Ramirez-Garcia; Aize Pellon; Aitor Rementeria; Idoia Buldain; Eliana Barreto-Bergter; Rodrigo Rollin-Pinheiro; Jardel Vieira De Meirelles; Mariana Ingrid D.S. Xisto; Stephane Ranque; Vladimir Havlicek; Patrick Vandeputte; Yohann Le Govic; Jean Philippe Bouchara; Sandrine Giraud; Sharon Chen; Johannes Rainer; Ana Alastruey-Izquierdo; Maria Teresa Martin-Gomez; Leyre M. López-Soria; Javier Peman; Carsten Schwarz; Anne Bernhardt; Kathrin Tintelnot; Javier Capilla; Adela Martin-Vicente; Jose Cano-Lira; Markus Nagl; Michaela Lackner; Laszlo Irinyi; Wieland Meyer; Sybren De Hoog; Fernando L. Hernando

doi:10.1093/mmy/myx113

Scedosporium and Lomentospora: An updated overview of underrated opportunists

Andoni Ramirez-Garcia, Aize Pellon, Aitor Rementeria, Idoia Buldain, Eliana Barreto-Bergter, Rodrigo Rollin-Pinheiro, Jardel Vieira De Meirelles, Mariana Ingrid D.S. Xisto, Stephane Ranque, Vladimir Havlicek, Patrick Vandeputte, Yohann Le Govic, Jean Philippe Bouchara, Sandrine Giraud, Sharon Chen, Johannes Rainer, Ana Alastruey-Izquierdo, Maria Teresa Martin-Gomez, Leyre M. López-Soria, Javier PemanCarsten Schwarz, Anne Bernhardt, Kathrin Tintelnot, Javier Capilla, Adela Martin-Vicente, Jose Cano-Lira, Markus Nagl, Michaela Lackner, Laszlo Irinyi, Wieland Meyer, Sybren De Hoog, Fernando L. Hernando

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

184 Citations (Scopus)

Abstract

Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.

Original language	English
Pages (from-to)	S102-S125
Journal	Medical Mycology
Volume	56
DOIs	https://doi.org/10.1093/mmy/myx113
Publication status	Published - 01 Apr 2018

Keywords

emergent
fungi
infection
pathogen

Access to Document

10.1093/mmy/myx113

http://www.mendeley.com/research/scedosporium-lomentospora-updated-overview-underrated-opportunists

Cite this

Ramirez-Garcia, A., Pellon, A., Rementeria, A., Buldain, I., Barreto-Bergter, E., Rollin-Pinheiro, R., De Meirelles, J. V., Xisto, M. I. D. S., Ranque, S., Havlicek, V., Vandeputte, P., Govic, Y. L., Bouchara, J. P., Giraud, S., Chen, S., Rainer, J., Alastruey-Izquierdo, A., Martin-Gomez, M. T., López-Soria, L. M., ... Hernando, F. L. (2018). Scedosporium and Lomentospora: An updated overview of underrated opportunists. Medical Mycology, 56, S102-S125. https://doi.org/10.1093/mmy/myx113

@article{fbff165afdfd4001b25f9ee759348c8d,

title = "Scedosporium and Lomentospora: An updated overview of underrated opportunists",

abstract = "Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.",

keywords = "emergent, fungi, infection, pathogen",

author = "Andoni Ramirez-Garcia and Aize Pellon and Aitor Rementeria and Idoia Buldain and Eliana Barreto-Bergter and Rodrigo Rollin-Pinheiro and {De Meirelles}, {Jardel Vieira} and Xisto, {Mariana Ingrid D.S.} and Stephane Ranque and Vladimir Havlicek and Patrick Vandeputte and Govic, {Yohann Le} and Bouchara, {Jean Philippe} and Sandrine Giraud and Sharon Chen and Johannes Rainer and Ana Alastruey-Izquierdo and Martin-Gomez, {Maria Teresa} and L{\'o}pez-Soria, {Leyre M.} and Javier Peman and Carsten Schwarz and Anne Bernhardt and Kathrin Tintelnot and Javier Capilla and Adela Martin-Vicente and Jose Cano-Lira and Markus Nagl and Michaela Lackner and Laszlo Irinyi and Wieland Meyer and {De Hoog}, Sybren and Hernando, {Fernando L.}",

year = "2018",

month = apr,

day = "1",

doi = "10.1093/mmy/myx113",

language = "English",

volume = "56",

pages = "S102--S125",

journal = "Medical Mycology",

issn = "1369-3786",

publisher = "Informa Healthcare",

}

Ramirez-Garcia, A, Pellon, A, Rementeria, A, Buldain, I, Barreto-Bergter, E, Rollin-Pinheiro, R, De Meirelles, JV, Xisto, MIDS, Ranque, S, Havlicek, V, Vandeputte, P, Govic, YL, Bouchara, JP, Giraud, S, Chen, S, Rainer, J, Alastruey-Izquierdo, A, Martin-Gomez, MT, López-Soria, LM, Peman, J, Schwarz, C, Bernhardt, A, Tintelnot, K, Capilla, J, Martin-Vicente, A, Cano-Lira, J, Nagl, M, Lackner, M, Irinyi, L, Meyer, W, De Hoog, S & Hernando, FL 2018, 'Scedosporium and Lomentospora: An updated overview of underrated opportunists', Medical Mycology, vol. 56, pp. S102-S125. https://doi.org/10.1093/mmy/myx113

TY - JOUR

T1 - Scedosporium and Lomentospora: An updated overview of underrated opportunists

AU - Ramirez-Garcia, Andoni

AU - Pellon, Aize

AU - Rementeria, Aitor

AU - Buldain, Idoia

AU - Barreto-Bergter, Eliana

AU - Rollin-Pinheiro, Rodrigo

AU - De Meirelles, Jardel Vieira

AU - Xisto, Mariana Ingrid D.S.

AU - Ranque, Stephane

AU - Havlicek, Vladimir

AU - Vandeputte, Patrick

AU - Govic, Yohann Le

AU - Bouchara, Jean Philippe

AU - Giraud, Sandrine

AU - Chen, Sharon

AU - Rainer, Johannes

AU - Alastruey-Izquierdo, Ana

AU - Martin-Gomez, Maria Teresa

AU - López-Soria, Leyre M.

AU - Peman, Javier

AU - Schwarz, Carsten

AU - Bernhardt, Anne

AU - Tintelnot, Kathrin

AU - Capilla, Javier

AU - Martin-Vicente, Adela

AU - Cano-Lira, Jose

AU - Nagl, Markus

AU - Lackner, Michaela

AU - Irinyi, Laszlo

AU - Meyer, Wieland

AU - De Hoog, Sybren

AU - Hernando, Fernando L.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.

AB - Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.

KW - emergent

KW - fungi

KW - infection

KW - pathogen

U2 - 10.1093/mmy/myx113

DO - 10.1093/mmy/myx113

M3 - Article

C2 - 29538735

SN - 1369-3786

VL - 56

SP - S102-S125

JO - Medical Mycology

JF - Medical Mycology

ER -

Scedosporium and Lomentospora: An updated overview of underrated opportunists

Abstract

Keywords

Access to Document

Fingerprint

Cite this