Science Forum: The Human Cell Atlas

Aviv Regev; Sarah A Teichmann; Eric S Lander; Ido Amit; Christophe Benoist; Ewan Birney; Bernd Bodenmiller; Peter J Campbell; Piero Carninci; Menna Clatworthy; Hans Clevers; Bart Deplancke; Ian Dunham; James Eberwine; Roland Eils; Wolfgang Enard; Andrew D. Farmer; Lars Fugger; Berthold Göttgens; Nir Hacohen; Muzlifah Haniffa; Martin Hemberg; Seung K Kim; Paul Klenerman; Arnold Kriegstein; Ed Lein; Sten Linnarsson; Emma Lundberg; Joakim Lundeberg; Partha Majumder; John C Marioni; Miriam Merad; Musa Mhlanga; Martijn Nawijn; Mihai G Netea; Garry Nolan; Dana Pe'er; Anthony Phillipakis; Chris P Ponting; Stephen R Quake; Wolf Reik; Orit Rozenblatt-Rosen; Joshua R Sanes; Rahul Satija; Ton N Schumacher; Alex K Shalek; Ehud Shapiro; Padmanee Sharma; Jay W Shin; Alexander van Oudenaarden

doi:10.7554/eLife.27041

Science Forum: The Human Cell Atlas

Aviv Regev, Sarah A Teichmann, Eric S Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter J Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew D. Farmer, Lars Fugger, Berthold Göttgens, Nir HacohenMuzlifah Haniffa, Martin Hemberg, Seung K Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Emma Lundberg, Joakim Lundeberg, Partha Majumder, John C Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai G Netea, Garry Nolan, Dana Pe'er, Anthony Phillipakis, Chris P Ponting, Stephen R Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua R Sanes, Rahul Satija, Ton N Schumacher, Alex K Shalek, Ehud Shapiro, Padmanee Sharma, Jay W Shin, Alexander van Oudenaarden,

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

1369 Citations (Scopus)

Abstract

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

Original language	English
Journal	eLife
Volume	6
DOIs	https://doi.org/10.7554/eLife.27041
Publication status	E-pub ahead of print - 05 Dec 2017

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Journal Article

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10.7554/eLife.27041

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Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P. J., Carninci, P., Clatworthy, M., Clevers, H., Deplancke, B., Dunham, I., Eberwine, J., Eils, R., Enard, W., Farmer, A. D., Fugger, L., Göttgens, B. (2017). Science Forum: The Human Cell Atlas. eLife, 6. Advance online publication. https://doi.org/10.7554/eLife.27041

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Regev, A, Teichmann, SA, Lander, ES, Amit, I, Benoist, C, Birney, E, Bodenmiller, B, Campbell, PJ, Carninci, P, Clatworthy, M, Clevers, H, Deplancke, B, Dunham, I, Eberwine, J, Eils, R, Enard, W, Farmer, AD, Fugger, L, Göttgens, B, Hacohen, N, Haniffa, M, Hemberg, M, Kim, SK, Klenerman, P, Kriegstein, A, Lein, E, Linnarsson, S, Lundberg, E, Lundeberg, J, Majumder, P, Marioni, JC, Merad, M, Mhlanga, M, Nawijn, M, Netea, MG, Nolan, G, Pe'er, D, Phillipakis, A, Ponting, CP, Quake, SR, Reik, W, Rozenblatt-Rosen, O, Sanes, JR, Satija, R, Schumacher, TN, Shalek, AK, Shapiro, E, Sharma, P, Shin, JW, van Oudenaarden, A 2017, 'Science Forum: The Human Cell Atlas', eLife, vol. 6. https://doi.org/10.7554/eLife.27041

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T1 - Science Forum

T2 - The Human Cell Atlas

AU - Regev, Aviv

AU - Teichmann, Sarah A

AU - Lander, Eric S

AU - Amit, Ido

AU - Benoist, Christophe

AU - Birney, Ewan

AU - Bodenmiller, Bernd

AU - Campbell, Peter J

AU - Carninci, Piero

AU - Clatworthy, Menna

AU - Clevers, Hans

AU - Deplancke, Bart

AU - Dunham, Ian

AU - Eberwine, James

AU - Eils, Roland

AU - Enard, Wolfgang

AU - Farmer, Andrew D.

AU - Fugger, Lars

AU - Göttgens, Berthold

AU - Hacohen, Nir

AU - Haniffa, Muzlifah

AU - Hemberg, Martin

AU - Kim, Seung K

AU - Klenerman, Paul

AU - Kriegstein, Arnold

AU - Lein, Ed

AU - Linnarsson, Sten

AU - Lundberg, Emma

AU - Lundeberg, Joakim

AU - Majumder, Partha

AU - Marioni, John C

AU - Merad, Miriam

AU - Mhlanga, Musa

AU - Nawijn, Martijn

AU - Netea, Mihai G

AU - Nolan, Garry

AU - Pe'er, Dana

AU - Phillipakis, Anthony

AU - Ponting, Chris P

AU - Quake, Stephen R

AU - Reik, Wolf

AU - Rozenblatt-Rosen, Orit

AU - Sanes, Joshua R

AU - Satija, Rahul

AU - Schumacher, Ton N

AU - Shalek, Alex K

AU - Shapiro, Ehud

AU - Sharma, Padmanee

AU - Shin, Jay W

AU - van Oudenaarden, Alexander

PY - 2017/12/5

Y1 - 2017/12/5

N2 - The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

AB - The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

KW - Journal Article

U2 - 10.7554/eLife.27041

DO - 10.7554/eLife.27041

M3 - Article

C2 - 29206104

SN - 2050-084X

VL - 6

JO - eLife

JF - eLife

ER -

Science Forum: The Human Cell Atlas

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