Scopulariopsis, a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro responses to antifungal drugs

M. Sandoval-Denis, D.A. Sutton, A.W. Fothergill, J. Cano-Lira, J. Gene, C.A. Decock, G.S. de Hoog, J. Guarro

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    69 Citations (Scopus)

    Abstract

    Ninety-nine isolates of clinical origin, tentatively identified as Scopulariopsis or Microascus, were morphologically and molecularly characterized by a combined analysis of the D1/D2 domains of the 28S rRNA gene and a fragment of the elongation factor 1-alpha gene (EF1-alpha) sequences. The most prevalent species was Scopulariopsis brevicaulis (49.4%), followed by Scopulariopsis gracilis (14.4%), Scopulariopsis brumptii (7.2%), Microascus cinereus (5.2%), the Scopulariopsis candida species complex (3.1%), and Microascus cirrosus (2.1%). The most common anatomic sites of isolation were the respiratory tract (61.6%), superficial tissue (19.2%), and deep tissue or fluid samples (19.2%). The antifungal susceptibilities of the isolates to eight drugs were tested in vitro, with all the drugs generally showing poor activity.
    Original languageEnglish
    Pages (from-to)3937-3943
    JournalJournal of Clinical Microbiology
    Volume51
    Issue number12
    DOIs
    Publication statusPublished - 2013

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