Scopulariopsis, a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro responses to antifungal drugs

M. Sandoval-Denis; D.A. Sutton; A.W. Fothergill; J. Cano-Lira; J. Gene; C.A. Decock; G.S. de Hoog; J. Guarro

doi:10.1128/JCM.01927-13

Scopulariopsis, a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro responses to antifungal drugs

M. Sandoval-Denis, D.A. Sutton, A.W. Fothergill, J. Cano-Lira, J. Gene, C.A. Decock, G.S. de Hoog, J. Guarro

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Abstract

Ninety-nine isolates of clinical origin, tentatively identified as Scopulariopsis or Microascus, were morphologically and molecularly characterized by a combined analysis of the D1/D2 domains of the 28S rRNA gene and a fragment of the elongation factor 1-alpha gene (EF1-alpha) sequences. The most prevalent species was Scopulariopsis brevicaulis (49.4%), followed by Scopulariopsis gracilis (14.4%), Scopulariopsis brumptii (7.2%), Microascus cinereus (5.2%), the Scopulariopsis candida species complex (3.1%), and Microascus cirrosus (2.1%). The most common anatomic sites of isolation were the respiratory tract (61.6%), superficial tissue (19.2%), and deep tissue or fluid samples (19.2%). The antifungal susceptibilities of the isolates to eight drugs were tested in vitro, with all the drugs generally showing poor activity.

Original language	English
Pages (from-to)	3937-3943
Journal	Journal of Clinical Microbiology
Volume	51
Issue number	12
DOIs	https://doi.org/10.1128/JCM.01927-13
Publication status	Published - 2013

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title = "Scopulariopsis, a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro responses to antifungal drugs",

abstract = "Ninety-nine isolates of clinical origin, tentatively identified as Scopulariopsis or Microascus, were morphologically and molecularly characterized by a combined analysis of the D1/D2 domains of the 28S rRNA gene and a fragment of the elongation factor 1-alpha gene (EF1-alpha) sequences. The most prevalent species was Scopulariopsis brevicaulis (49.4%), followed by Scopulariopsis gracilis (14.4%), Scopulariopsis brumptii (7.2%), Microascus cinereus (5.2%), the Scopulariopsis candida species complex (3.1%), and Microascus cirrosus (2.1%). The most common anatomic sites of isolation were the respiratory tract (61.6%), superficial tissue (19.2%), and deep tissue or fluid samples (19.2%). The antifungal susceptibilities of the isolates to eight drugs were tested in vitro, with all the drugs generally showing poor activity.",

author = "M. Sandoval-Denis and D.A. Sutton and A.W. Fothergill and J. Cano-Lira and J. Gene and C.A. Decock and {de Hoog}, G.S. and J. Guarro",

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TY - JOUR

T1 - Scopulariopsis, a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro responses to antifungal drugs

AU - Sandoval-Denis, M.

AU - Sutton, D.A.

AU - Fothergill, A.W.

AU - Cano-Lira, J.

AU - Gene, J.

AU - Decock, C.A.

AU - de Hoog, G.S.

AU - Guarro, J.

N1 - Reporting year: 2013

PY - 2013

Y1 - 2013

N2 - Ninety-nine isolates of clinical origin, tentatively identified as Scopulariopsis or Microascus, were morphologically and molecularly characterized by a combined analysis of the D1/D2 domains of the 28S rRNA gene and a fragment of the elongation factor 1-alpha gene (EF1-alpha) sequences. The most prevalent species was Scopulariopsis brevicaulis (49.4%), followed by Scopulariopsis gracilis (14.4%), Scopulariopsis brumptii (7.2%), Microascus cinereus (5.2%), the Scopulariopsis candida species complex (3.1%), and Microascus cirrosus (2.1%). The most common anatomic sites of isolation were the respiratory tract (61.6%), superficial tissue (19.2%), and deep tissue or fluid samples (19.2%). The antifungal susceptibilities of the isolates to eight drugs were tested in vitro, with all the drugs generally showing poor activity.

AB - Ninety-nine isolates of clinical origin, tentatively identified as Scopulariopsis or Microascus, were morphologically and molecularly characterized by a combined analysis of the D1/D2 domains of the 28S rRNA gene and a fragment of the elongation factor 1-alpha gene (EF1-alpha) sequences. The most prevalent species was Scopulariopsis brevicaulis (49.4%), followed by Scopulariopsis gracilis (14.4%), Scopulariopsis brumptii (7.2%), Microascus cinereus (5.2%), the Scopulariopsis candida species complex (3.1%), and Microascus cirrosus (2.1%). The most common anatomic sites of isolation were the respiratory tract (61.6%), superficial tissue (19.2%), and deep tissue or fluid samples (19.2%). The antifungal susceptibilities of the isolates to eight drugs were tested in vitro, with all the drugs generally showing poor activity.

U2 - 10.1128/JCM.01927-13

DO - 10.1128/JCM.01927-13

M3 - Article

SN - 0095-1137

VL - 51

SP - 3937

EP - 3943

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 12

ER -

Scopulariopsis, a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro responses to antifungal drugs

Abstract

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