Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis.

J. Bakkers, M.C. Verhoeven, S. Abdelilah-Seyfried

Research output: Contribution to journal/periodicalArticleScientificpeer-review

48 Citations (Scopus)


Although vertebrates appear bilaterally symmetric on the outside, various internal organs, including the heart, are asymmetric with respect to their position and/or their orientation based on the left/right (L/R) axis. The L/R axis is determined during embryo development. Determination of the L/R axis is fundamentally different from the determination of the anterior-posterior or the dorsal-ventral axis. In all vertebrates a ciliated organ has been described that induces a left-sided gene expression program, which includes Nodal expression in the left lateral plate mesoderm. To have a better understanding of organ laterality it is important to understand how L/R patterning induces cellular responses during organogenesis. In this review, we discuss the current understanding of the mechanisms of L/R patterning during zebrafish development and focus on how this affects cardiac morphogenesis. Several recent studies have provided unprecedented insights into the intimate link between L/R signaling and the cellular responses that drive morphogenesis of this organ.
Original languageEnglish
Pages (from-to)213-220
JournalDevelopmental Biology
Issue number2
Publication statusPublished - 2009


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