Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish

M.D. Clark; V. Guryev; E. de Bruijn; I.J. Nijman; M. Tada; C. Wilson; P. Deloukas; J.H. Postlethwait; E. Cuppen; D.L. Stemple

doi:10.1016/B978-0-12-374814-0.00013-6

Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish

M.D. Clark, V. Guryev, E. de Bruijn, I.J. Nijman, M. Tada, C. Wilson, P. Deloukas, J.H. Postlethwait, E. Cuppen, D.L. Stemple

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

5 Citations (Scopus)

Abstract

Despite considerable genetic and genomic resources the positional cloning of forward mutations remains a slow and manually intensive task, typically using gel based genotyping and sequential rounds of mapping. We have used the latest genetic resources and genotyping technologies to develop two commercially available SNP panels of thousands of markers that can be used to speed up positional cloning.

Original language	English
Pages (from-to)	219-235
Journal	Methods in Cell Biology
Volume	104
DOIs	https://doi.org/10.1016/B978-0-12-374814-0.00013-6
Publication status	Published - 2011

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title = "Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish",

abstract = "Despite considerable genetic and genomic resources the positional cloning of forward mutations remains a slow and manually intensive task, typically using gel based genotyping and sequential rounds of mapping. We have used the latest genetic resources and genotyping technologies to develop two commercially available SNP panels of thousands of markers that can be used to speed up positional cloning.",

author = "M.D. Clark and V. Guryev and {de Bruijn}, E. and I.J. Nijman and M. Tada and C. Wilson and P. Deloukas and J.H. Postlethwait and E. Cuppen and D.L. Stemple",

note = "Reporting year: 2011",

year = "2011",

doi = "10.1016/B978-0-12-374814-0.00013-6",

language = "English",

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journal = "Methods in Cell Biology",

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TY - JOUR

T1 - Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish

AU - Clark, M.D.

AU - Guryev, V.

AU - de Bruijn, E.

AU - Nijman, I.J.

AU - Tada, M.

AU - Wilson, C.

AU - Deloukas, P.

AU - Postlethwait, J.H.

AU - Cuppen, E.

AU - Stemple, D.L.

N1 - Reporting year: 2011

PY - 2011

Y1 - 2011

N2 - Despite considerable genetic and genomic resources the positional cloning of forward mutations remains a slow and manually intensive task, typically using gel based genotyping and sequential rounds of mapping. We have used the latest genetic resources and genotyping technologies to develop two commercially available SNP panels of thousands of markers that can be used to speed up positional cloning.

AB - Despite considerable genetic and genomic resources the positional cloning of forward mutations remains a slow and manually intensive task, typically using gel based genotyping and sequential rounds of mapping. We have used the latest genetic resources and genotyping technologies to develop two commercially available SNP panels of thousands of markers that can be used to speed up positional cloning.

U2 - 10.1016/B978-0-12-374814-0.00013-6

DO - 10.1016/B978-0-12-374814-0.00013-6

M3 - Article

SN - 0091-679X

VL - 104

SP - 219

EP - 235

JO - Methods in Cell Biology

JF - Methods in Cell Biology

ER -

Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish

Abstract

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