Sleep disturbances and incident risk of major depressive disorder in a population-based cohort

Geoffroy Solelhac; Théo Imler; Marie-Pierre F Strippoli; Nicola Andrea Marchi; Mathieu Berger; Jose Haba-Rubio; Tifenn Raffray; Virginie Bayon; Anne Sophie Lombardi; Setareh Ranjbar; Francesca Siclari; Peter Vollenweider; Pedro Marques-Vidal; Pierre-Alexis Geoffroy; Damien Léger; Aurélie Stephan; Martin Preisig; Raphaël Heinzer

doi:10.1016/j.psychres.2024.115934

Sleep disturbances and incident risk of major depressive disorder in a population-based cohort

Geoffroy Solelhac, Théo Imler, Marie-Pierre F Strippoli, Nicola Andrea Marchi, Mathieu Berger, Jose Haba-Rubio, Tifenn Raffray, Virginie Bayon, Anne Sophie Lombardi, Setareh Ranjbar, Francesca Siclari, Peter Vollenweider, Pedro Marques-Vidal, Pierre-Alexis Geoffroy, Damien Léger, Aurélie Stephan, Martin Preisig, Raphaël Heinzer

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Abstract

Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022-1.103], p = 0.002 and 1.437 [1.064-1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064-1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463-0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.

Original language	English
Pages (from-to)	115934
Journal	Psychiatry research
Volume	338
DOIs	https://doi.org/10.1016/j.psychres.2024.115934
Publication status	Published - 03 Jun 2024

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10.1016/j.psychres.2024.115934

Solelhac2024Final published version, 2.05 MBLicence: CC BY

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Solelhac, G., Imler, T., Strippoli, M.-P. F., Marchi, N. A., Berger, M., Haba-Rubio, J., Raffray, T., Bayon, V., Lombardi, A. S., Ranjbar, S., Siclari, F., Vollenweider, P., Marques-Vidal, P., Geoffroy, P.-A., Léger, D., Stephan, A., Preisig, M., & Heinzer, R. (2024). Sleep disturbances and incident risk of major depressive disorder in a population-based cohort. Psychiatry research, 338, 115934. https://doi.org/10.1016/j.psychres.2024.115934

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title = "Sleep disturbances and incident risk of major depressive disorder in a population-based cohort",

abstract = "Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022-1.103], p = 0.002 and 1.437 [1.064-1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064-1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463-0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.",

author = "Geoffroy Solelhac and Th{\'e}o Imler and Strippoli, {Marie-Pierre F} and Marchi, {Nicola Andrea} and Mathieu Berger and Jose Haba-Rubio and Tifenn Raffray and Virginie Bayon and Lombardi, {Anne Sophie} and Setareh Ranjbar and Francesca Siclari and Peter Vollenweider and Pedro Marques-Vidal and Pierre-Alexis Geoffroy and Damien L{\'e}ger and Aur{\'e}lie Stephan and Martin Preisig and Rapha{\"e}l Heinzer",

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Solelhac, G, Imler, T, Strippoli, M-PF, Marchi, NA, Berger, M, Haba-Rubio, J, Raffray, T, Bayon, V, Lombardi, AS, Ranjbar, S, Siclari, F, Vollenweider, P, Marques-Vidal, P, Geoffroy, P-A, Léger, D, Stephan, A, Preisig, M & Heinzer, R 2024, 'Sleep disturbances and incident risk of major depressive disorder in a population-based cohort', Psychiatry research, vol. 338, pp. 115934. https://doi.org/10.1016/j.psychres.2024.115934

TY - JOUR

T1 - Sleep disturbances and incident risk of major depressive disorder in a population-based cohort

AU - Solelhac, Geoffroy

AU - Imler, Théo

AU - Strippoli, Marie-Pierre F

AU - Marchi, Nicola Andrea

AU - Berger, Mathieu

AU - Haba-Rubio, Jose

AU - Raffray, Tifenn

AU - Bayon, Virginie

AU - Lombardi, Anne Sophie

AU - Ranjbar, Setareh

AU - Siclari, Francesca

AU - Vollenweider, Peter

AU - Marques-Vidal, Pedro

AU - Geoffroy, Pierre-Alexis

AU - Léger, Damien

AU - Stephan, Aurélie

AU - Preisig, Martin

AU - Heinzer, Raphaël

PY - 2024/6/3

Y1 - 2024/6/3

N2 - Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022-1.103], p = 0.002 and 1.437 [1.064-1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064-1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463-0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.

AB - Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022-1.103], p = 0.002 and 1.437 [1.064-1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064-1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463-0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.

U2 - 10.1016/j.psychres.2024.115934

DO - 10.1016/j.psychres.2024.115934

M3 - Article

C2 - 38833937

SN - 0165-1781

VL - 338

SP - 115934

JO - Psychiatry research

JF - Psychiatry research

ER -

Sleep disturbances and incident risk of major depressive disorder in a population-based cohort

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