Spared perilesional V1 activity underlies training-induced recovery of luminance detection sensitivity in cortically-blind patients

TY - JOUR

T1 - Spared perilesional V1 activity underlies training-induced recovery of luminance detection sensitivity in cortically-blind patients

AU - Barbot, Antoine

AU - Das, Anasuya

AU - Melnick, Michael D

AU - Cavanaugh, Matthew R

AU - Merriam, Elisha P

AU - Heeger, David J

AU - Huxlin, Krystel R

N1 - © 2021. The Author(s).

PY - 2021/10/20

Y1 - 2021/10/20

N2 - Damage to the primary visual cortex (V1) causes homonymous visual-field loss long considered intractable. Multiple studies now show that perceptual training can restore visual functions in chronic cortically-induced blindness (CB). A popular hypothesis is that training can harness residual visual functions by recruiting intact extrageniculostriate pathways. Training may also induce plastic changes within spared regions of the damaged V1. Here, we link changes in luminance detection sensitivity with retinotopic fMRI activity before and after visual discrimination training in eleven patients with chronic, stroke-induced CB. We show that spared V1 activity representing perimetrically-blind locations prior to training predicts the amount of training-induced recovery of luminance detection sensitivity. Additionally, training results in an enlargement of population receptive fields in perilesional V1, which increases blind-field coverage and may support further recovery with subsequent training. These findings uncover fundamental changes in perilesional V1 cortex underlying training-induced restoration of conscious luminance detection sensitivity in CB.

AB - Damage to the primary visual cortex (V1) causes homonymous visual-field loss long considered intractable. Multiple studies now show that perceptual training can restore visual functions in chronic cortically-induced blindness (CB). A popular hypothesis is that training can harness residual visual functions by recruiting intact extrageniculostriate pathways. Training may also induce plastic changes within spared regions of the damaged V1. Here, we link changes in luminance detection sensitivity with retinotopic fMRI activity before and after visual discrimination training in eleven patients with chronic, stroke-induced CB. We show that spared V1 activity representing perimetrically-blind locations prior to training predicts the amount of training-induced recovery of luminance detection sensitivity. Additionally, training results in an enlargement of population receptive fields in perilesional V1, which increases blind-field coverage and may support further recovery with subsequent training. These findings uncover fundamental changes in perilesional V1 cortex underlying training-induced restoration of conscious luminance detection sensitivity in CB.

U2 - 10.1038/s41467-021-26345-1

DO - 10.1038/s41467-021-26345-1

M3 - Article

C2 - 34671032

SN - 2041-1723

VL - 12

SP - 6102

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -