Spatial chromatin organization and gene regulation at the nuclear lamina

Isabel Guerreiro; Jop Kind

doi:10.1016/j.gde.2019.04.008

Spatial chromatin organization and gene regulation at the nuclear lamina

Isabel Guerreiro, Jop Kind

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

38 Citations (Scopus)

Abstract

The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.

Original language	English
Pages (from-to)	19-25
Number of pages	7
Journal	Current Opinion in Genetics & Development
Volume	55
DOIs	https://doi.org/10.1016/j.gde.2019.04.008
Publication status	Published - Apr 2019

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10.1016/j.gde.2019.04.008

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title = "Spatial chromatin organization and gene regulation at the nuclear lamina",

abstract = "The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.",

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AU - Kind, Jop

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AB - The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.

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DO - 10.1016/j.gde.2019.04.008

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JO - Current Opinion in Genetics & Development

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Spatial chromatin organization and gene regulation at the nuclear lamina

Abstract

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