Spatial chromatin organization and gene regulation at the nuclear lamina

Isabel Guerreiro, Jop Kind

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalCurrent Opinion in Genetics & Development
Volume55
DOIs
Publication statusPublished - Apr 2019

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