Spatial chromatin organization and gene regulation at the nuclear lamina

Isabel Guerreiro; Jop Kind

doi:10.1016/j.gde.2019.04.008

Spatial chromatin organization and gene regulation at the nuclear lamina

Isabel Guerreiro, Jop Kind

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.

Original language	English
Pages (from-to)	19-25
Number of pages	7
Journal	Current Opinion in Genetics & Development
Volume	55
DOIs	https://doi.org/10.1016/j.gde.2019.04.008
Publication status	Published - Apr 2019

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10.1016/j.gde.2019.04.008

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title = "Spatial chromatin organization and gene regulation at the nuclear lamina",

abstract = "The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.",

author = "Isabel Guerreiro and Jop Kind",

year = "2019",

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AU - Guerreiro, Isabel

AU - Kind, Jop

PY - 2019/4

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AB - The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.

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DO - 10.1016/j.gde.2019.04.008

M3 - Article

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VL - 55

SP - 19

EP - 25

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

ER -

Spatial chromatin organization and gene regulation at the nuclear lamina

Abstract

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