Spatially resolved transcriptomics and beyond

Nicola Crosetto, Magda Bienko, Alexander van Oudenaarden

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular localization of analysed nucleic acids. In this Innovation article, we summarize pioneering technologies that enable spatially resolved transcriptomics and discuss how these methods have the potential to extend beyond transcriptomics to encompass spatially resolved genomics, proteomics and possibly other omic disciplines.

Original languageEnglish
Pages (from-to)57-66
Number of pages10
JournalNature Reviews Genetics
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Gene Expression Profiling
  • High-Throughput Screening Assays
  • Molecular Imaging
  • Sequence Analysis
  • Single-Cell Analysis
  • Spatial Analysis

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