@article{4cf1b8a091e9435eb5ba3f19091858e7,
title = "Species-specific toxicity of copper nanoparticles among mammalian and piscine cell lines",
abstract = "The four copper nanoparticles (CuNPs) with the size of 25, 50, 78 and 100 nm and one type of micron-sized particles (MPs) (similar to 500 nm) were exposed to two mammalian (H4IIE and HepG2) and two piscine (PLHC-1 and RTH-149) cell lines to test the species-specific toxicities of CuNPs. The results showed that the morphologies, ion release and size of the particles all played an important role when investigating the toxicity. Furthermore, the authors found that the particle forms of CuNPs in suspensions highly contribute to the toxicity in all exposed cell lines whereas copper ions (Cu2+) only caused significant responses in mammalian cell lines, indicating the species-specific toxicity of CuNPs. This study revealed that the morphologies, ion release rate of NPs as well as the species-specific vulnerabilities of cells should all be considered when explaining and extrapolating toxicity test results among particles and among species.",
keywords = "copper nanoparticles mammalian and fish cell lines size and morphology of NPs species-specific cytotoxicity reactive oxygen species dependent toxicity particles tio2 size Science & Technology - Other Topics Toxicology",
author = "L. Song and M. Connolly and Fernandez-Cruz, {M. L.} and Vijver, {M. G.} and M. Fernandez and E. Conde and {de Snoo}, {G. R.} and Wjgm Peijnenburg and Navas, {J. M.}",
note = "ISI Document Delivery No.: 267VP Times Cited: 56 Cited Reference Count: 23 Song, Lan Connolly, Mona Fernandez-Cruz, Maria L. Vijver, Martina G. Fernandez, Marta Conde, Estefania de Snoo, Geert R. Peijnenburg, Willie J. G. M. Navas, Jose M. SONG, LAN/G-2153-2019; Connolly, Mona/T-6599-2018; Peijnenburg, Willie J.G.M/E-1120-2014; Vilda, Estefania Conde/AAB-2010-2019; Fernandez-Cruz, Maria Luisa/Q-6762-2017; Navas, Jose M/I-9328-2012 Connolly, Mona/0000-0003-3574-8564; Peijnenburg, Willie J.G.M/0000-0003-2958-9149; Fernandez-Cruz, Maria Luisa/0000-0001-5988-1939; Navas, Jose M/0000-0002-7644-8499; Conde vida, Estefania/0000-0002-7879-0896; Vijver, Martina/0000-0003-2999-1605 Environmental ChemOinformatics Marie Curie Initial Training Network (ECO-ITN) within the seventh research framework programme of the European UnionEuropean Union (EU) [238701]; VENI grant [863.08.023]; Netherlands Organization for Scientific Research (NWO)Netherlands Organization for Scientific Research (NWO); RIVM; INIA projectInstituto de Investigacion Agropecuaria (INIA) [AT2011-0001] L Song and M Connolly have contributed equally to this work. Both of them are sponsored by the Environmental ChemOinformatics Marie Curie Initial Training Network (ECO-ITN) within the seventh research framework programme of the European Union (238701). MG Vijver is supported via VENI grant (863.08.023) awarded by The Netherlands Organization for Scientific Research (NWO). Part of the work was performed within the framework of the RIVM sponsored project {"}IRAN{"} and the INIA project AT2011-0001. 56 0 62 Taylor & francis ltd Abingdon 1743-5404 <Go to ISI>://WOS:000328126700004",
year = "2014",
doi = "10.3109/17435390.2013.790997",
language = "English",
volume = "8",
pages = "383--393",
journal = "Nanotoxicology",
issn = "1743-5390",
publisher = "Taylor & Francis Group",
number = "4",
}