TY - JOUR
T1 - Strategies for homeostatic stem cell self-renewal in adult tissues
AU - Simons, B.D.
AU - Clevers, H.
N1 - Reporting year: 2011
PY - 2011
Y1 - 2011
N2 - In adult tissues, an exquisite balance exists between stem cell proliferation and the generation of differentiated offspring. Classically, it has been argued that this balance is obtained at the level of a single stem cell, which divides strictly into a new stem cell and a progenitor. However, recent evidence suggests that balance can also be achieved at the level of the stem cell population. Some stem cells might be lost due to differentiation or damage, whereas others divide symmetrically to fill this gap. Here, we consider the general strategies for stem cell self-renewal and review the evidence for stochastic stem cell fate in adult tissues across a range of tissue types and organisms. [KEYWORDS: Adult Stem Cells/ cytology/metabolism, Animals, Cell Division, Cell Lineage, Drosophila/cytology, Humans]
AB - In adult tissues, an exquisite balance exists between stem cell proliferation and the generation of differentiated offspring. Classically, it has been argued that this balance is obtained at the level of a single stem cell, which divides strictly into a new stem cell and a progenitor. However, recent evidence suggests that balance can also be achieved at the level of the stem cell population. Some stem cells might be lost due to differentiation or damage, whereas others divide symmetrically to fill this gap. Here, we consider the general strategies for stem cell self-renewal and review the evidence for stochastic stem cell fate in adult tissues across a range of tissue types and organisms. [KEYWORDS: Adult Stem Cells/ cytology/metabolism, Animals, Cell Division, Cell Lineage, Drosophila/cytology, Humans]
U2 - 10.1016/j.cell.2011.05.033
DO - 10.1016/j.cell.2011.05.033
M3 - Article
SN - 0092-8674
VL - 145
SP - 851
EP - 862
JO - Cell
JF - Cell
IS - 6
ER -