Strategies for homeostatic stem cell self-renewal in adult tissues

B.D. Simons, H. Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

381 Citations (Scopus)

Abstract

In adult tissues, an exquisite balance exists between stem cell proliferation and the generation of differentiated offspring. Classically, it has been argued that this balance is obtained at the level of a single stem cell, which divides strictly into a new stem cell and a progenitor. However, recent evidence suggests that balance can also be achieved at the level of the stem cell population. Some stem cells might be lost due to differentiation or damage, whereas others divide symmetrically to fill this gap. Here, we consider the general strategies for stem cell self-renewal and review the evidence for stochastic stem cell fate in adult tissues across a range of tissue types and organisms. [KEYWORDS: Adult Stem Cells/ cytology/metabolism, Animals, Cell Division, Cell Lineage, Drosophila/cytology, Humans]
Original languageEnglish
Pages (from-to)851-862
JournalCell
Volume145
Issue number6
DOIs
Publication statusPublished - 2011

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