Stress-Axis Regulation by Vitamin D-3 in Multiple Sclerosis

Linda Rolf, Jan Damoiseaux, I. Huitinga, Dorien Kimenai, Jody van den Ouweland, Raymond Hupperts, Joost Smolders

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Multiple sclerosis (MS) has been associated with both a poor vitamin D
status and hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis. Since nuclear receptor ligands may regulate each other, we explored the association of vitamin D3 supplements with circadian cortisol levels in a double-blind and placebo-controlled supplementation study.
Original languageEnglish
Article number263
JournalFrontiers in Neurology
Publication statusPublished - Apr 2018


  • Cortisol
  • HPA-axis
  • multiple sclerosis
  • supplementation
  • vitamin D

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