Stress-Axis Regulation by Vitamin D-3 in Multiple Sclerosis

Linda Rolf; Jan Damoiseaux; I. Huitinga; Dorien Kimenai; Jody van den Ouweland; Raymond Hupperts; Joost Smolders

doi:10.3389/fneur.2018.00263

Stress-Axis Regulation by Vitamin D-3 in Multiple Sclerosis

Linda Rolf, Jan Damoiseaux, I. Huitinga, Dorien Kimenai, Jody van den Ouweland, Raymond Hupperts, Joost Smolders

Netherlands Institute for Neuroscience (NIN)

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Abstract

Multiple sclerosis (MS) has been associated with both a poor vitamin D
status and hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis. Since nuclear receptor ligands may regulate each other, we explored the association of vitamin D3 supplements with circadian cortisol levels in a double-blind and placebo-controlled supplementation study.

Original language	English
Article number	263
Journal	Frontiers in Neurology
Volume	9
DOIs	https://doi.org/10.3389/fneur.2018.00263
Publication status	Published - Apr 2018

Keywords

Cortisol
HPA-axis
multiple sclerosis
supplementation
vitamin D

Access to Document

10.3389/fneur.2018.00263

Rolf2018FrontneurolFinal published version, 1.43 MB

Cite this

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title = "Stress-Axis Regulation by Vitamin D-3 in Multiple Sclerosis",

abstract = "Multiple sclerosis (MS) has been associated with both a poor vitamin Dstatus and hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis. Since nuclear receptor ligands may regulate each other, we explored the association of vitamin D3 supplements with circadian cortisol levels in a double-blind and placebo-controlled supplementation study.",

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AU - Hupperts, Raymond

AU - Smolders, Joost

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KW - supplementation

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