Studying Kinetochore Kinases

Adrian T Saurin, Geert J P L Kops

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

Original languageEnglish
Pages (from-to)333-47
Number of pages15
JournalMethods in Molecular Biology
Volume1413
DOIs
Publication statusPublished - 2016

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