Studying Kinetochore Kinases

Adrian T Saurin; Geert J P L Kops

doi:10.1007/978-1-4939-3542-0_21

Studying Kinetochore Kinases

Adrian T Saurin, Geert J P L Kops

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

5 Citations (Scopus)

Abstract

Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

Original language	English
Pages (from-to)	333-47
Number of pages	15
Journal	Methods in Molecular Biology
Volume	1413
DOIs	https://doi.org/10.1007/978-1-4939-3542-0_21
Publication status	Published - 2016

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10.1007/978-1-4939-3542-0_21

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title = "Studying Kinetochore Kinases",

abstract = "Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.",

author = "Saurin, {Adrian T} and Kops, {Geert J P L}",

year = "2016",

doi = "10.1007/978-1-4939-3542-0_21",

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journal = "Methods in Molecular Biology",

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T1 - Studying Kinetochore Kinases

AU - Saurin, Adrian T

AU - Kops, Geert J P L

PY - 2016

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N2 - Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

AB - Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

U2 - 10.1007/978-1-4939-3542-0_21

DO - 10.1007/978-1-4939-3542-0_21

M3 - Article

C2 - 27193859

SN - 1064-3745

VL - 1413

SP - 333

EP - 347

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

ER -

Studying Kinetochore Kinases

Abstract

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