Subcutaneous infection by Ochroconis mirabilis in an immunocompetent patient

Dongmei Shi; Guixia Lu; Huan Mei; G Sybren de Hoog; Kittipan Samerpitak; Shuwen Deng; Yongnian Shen; Weida Liu

doi:10.1016/j.mmcr.2016.04.007

Subcutaneous infection by Ochroconis mirabilis in an immunocompetent patient

Dongmei Shi, Guixia Lu, Huan Mei, G Sybren de Hoog, Kittipan Samerpitak, Shuwen Deng, Yongnian Shen, Weida Liu

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

Recently, the taxonomy of Ochroconis (Ascomycota, Pezizomycotina, Venturiales, Sympoventuriaceae) has been revised with the recognition of an additional genus, Verruconis. Ochroconis comprises mesophilic saprobes that occasionally infect vertebrates which mostly are cold-blooded, while Verruconis contains thermophilic species which is a neurotrope in humans and birds. On the basis of molecular data it is noted that only a single Ochroconis species regularly infects immunocompetent human hosts. Here we report a subcutaneous infection due to Ochroconis mirabilis in a 50-year-old immunocompetent female patient. In vitro antifungal susceptibility tests revealed that terbinafine was the most effective drug. The patient was successfully cured with oral administration of terbinafine 250 mg daily in combination with 3 times of topical ALA-photodynamic therapy for 9 months.

Original language	English
Pages (from-to)	44-47
Number of pages	4
Journal	Medical Mycology Case Reports
Volume	11
DOIs	https://doi.org/10.1016/j.mmcr.2016.04.007 https://doi.org/10.1016/j.mmcr.2016.04.007
Publication status	Published - Mar 2016

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@article{7aea67a297b74e5c965ddb1bcf387389,

title = "Subcutaneous infection by Ochroconis mirabilis in an immunocompetent patient",

abstract = "Recently, the taxonomy of Ochroconis (Ascomycota, Pezizomycotina, Venturiales, Sympoventuriaceae) has been revised with the recognition of an additional genus, Verruconis. Ochroconis comprises mesophilic saprobes that occasionally infect vertebrates which mostly are cold-blooded, while Verruconis contains thermophilic species which is a neurotrope in humans and birds. On the basis of molecular data it is noted that only a single Ochroconis species regularly infects immunocompetent human hosts. Here we report a subcutaneous infection due to Ochroconis mirabilis in a 50-year-old immunocompetent female patient. In vitro antifungal susceptibility tests revealed that terbinafine was the most effective drug. The patient was successfully cured with oral administration of terbinafine 250 mg daily in combination with 3 times of topical ALA-photodynamic therapy for 9 months.",

author = "Dongmei Shi and Guixia Lu and Huan Mei and {de Hoog}, {G Sybren} and Kittipan Samerpitak and Shuwen Deng and Yongnian Shen and Weida Liu",

year = "2016",

month = mar,

doi = "10.1016/j.mmcr.2016.04.007",

language = "English",

volume = "11",

pages = "44--47",

journal = "Medical Mycology Case Reports",

issn = "2211-7539",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Subcutaneous infection by Ochroconis mirabilis in an immunocompetent patient

AU - Shi, Dongmei

AU - Lu, Guixia

AU - Mei, Huan

AU - de Hoog, G Sybren

AU - Samerpitak, Kittipan

AU - Deng, Shuwen

AU - Shen, Yongnian

AU - Liu, Weida

PY - 2016/3

Y1 - 2016/3

N2 - Recently, the taxonomy of Ochroconis (Ascomycota, Pezizomycotina, Venturiales, Sympoventuriaceae) has been revised with the recognition of an additional genus, Verruconis. Ochroconis comprises mesophilic saprobes that occasionally infect vertebrates which mostly are cold-blooded, while Verruconis contains thermophilic species which is a neurotrope in humans and birds. On the basis of molecular data it is noted that only a single Ochroconis species regularly infects immunocompetent human hosts. Here we report a subcutaneous infection due to Ochroconis mirabilis in a 50-year-old immunocompetent female patient. In vitro antifungal susceptibility tests revealed that terbinafine was the most effective drug. The patient was successfully cured with oral administration of terbinafine 250 mg daily in combination with 3 times of topical ALA-photodynamic therapy for 9 months.

AB - Recently, the taxonomy of Ochroconis (Ascomycota, Pezizomycotina, Venturiales, Sympoventuriaceae) has been revised with the recognition of an additional genus, Verruconis. Ochroconis comprises mesophilic saprobes that occasionally infect vertebrates which mostly are cold-blooded, while Verruconis contains thermophilic species which is a neurotrope in humans and birds. On the basis of molecular data it is noted that only a single Ochroconis species regularly infects immunocompetent human hosts. Here we report a subcutaneous infection due to Ochroconis mirabilis in a 50-year-old immunocompetent female patient. In vitro antifungal susceptibility tests revealed that terbinafine was the most effective drug. The patient was successfully cured with oral administration of terbinafine 250 mg daily in combination with 3 times of topical ALA-photodynamic therapy for 9 months.

U2 - 10.1016/j.mmcr.2016.04.007

DO - 10.1016/j.mmcr.2016.04.007

M3 - Article

C2 - 27182484

VL - 11

SP - 44

EP - 47

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

SN - 2211-7539

ER -

Subcutaneous infection by Ochroconis mirabilis in an immunocompetent patient

Abstract

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