Successful Isavuconazole Salvage Therapy for a Cryptococcus deuterogattii (AFLP6/VGII) Disseminated Infection in a European Immunocompetent Patient

Maria Soledad Cuetara, Juan José Jusdado Ruiz-Capillas, Maria Pilar Nuñez-Valentin, Elena Rodríguez Garcia, Elena Garcia-Benayas, Ricardo Rojo-Amigo, Jose Carlos Rodriguez-Gallego, Ferry Hagen, María Francisca Colom

Research output: Contribution to journal/periodicalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Members of the Cryptococcus gattii species complex are notorious causes of cryptococcosis as they often cause severe, life-threatening infections. Here we describe a case of a severe disseminated C. deuterogattii infection in a previously healthy patient who was initially treated with amphotericin B, 5-fluorocytosine and fluconazole, which led to a good neurological response, but the infection in the lungs remained unaltered and was not completely resolved until switching the antifungal therapy to isavuconazole. The infection was likely acquired during a one-month stay at the Azores Islands, Portugal. Environmental sampling did not yield any cryptococcal isolate; therefore, the source of this apparent autochthonous case could not be determined. Molecular typing showed that the cultured C. deuterogattii isolates were closely related to the Vancouver Island outbreak-genotype.

Original languageEnglish
Pages (from-to)507-518
Number of pages12
JournalMycopathologia
Volume186
Issue number4
DOIs
Publication statusPublished - Aug 2021

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