Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region

Anne Debourgogne; Ferry Hagen; Narcisse Elenga; Laurence Long; Denis Blanchet; Vincent Veron; Olivier Lortholary; Bernard Carme; Christine Aznar

doi:10.1016/j.riam.2012.01.008

Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region

Anne Debourgogne, Ferry Hagen, Narcisse Elenga, Laurence Long, Denis Blanchet, Vincent Veron, Olivier Lortholary, Bernard Carme, Christine Aznar

Westerdijk Fungal Biodiversity Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.

Original language	English
Pages (from-to)	210-3
Number of pages	4
Journal	Revista Iberoamericana de Micologia
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.riam.2012.01.008
Publication status	Published - 01 Mar 2012

Keywords

Central Nervous System Fungal Infections/therapy
Child, Preschool
Cryptococcosis/therapy
Cryptococcus gattii
Female
French Guiana
Humans
Remission Induction

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10.1016/j.riam.2012.01.008

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Debourgogne, Anne ; Hagen, Ferry ; Elenga, Narcisse ; Long, Laurence ; Blanchet, Denis ; Veron, Vincent ; Lortholary, Olivier ; Carme, Bernard ; Aznar, Christine. / Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region. In: Revista Iberoamericana de Micologia. 2012 ; Vol. 29, No. 4. pp. 210-3.

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title = "Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region",

abstract = "Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.",

keywords = "Central Nervous System Fungal Infections/therapy, Child, Preschool, Cryptococcosis/therapy, Cryptococcus gattii, Female, French Guiana, Humans, Remission Induction",

author = "Anne Debourgogne and Ferry Hagen and Narcisse Elenga and Laurence Long and Denis Blanchet and Vincent Veron and Olivier Lortholary and Bernard Carme and Christine Aznar",

year = "2012",

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doi = "10.1016/j.riam.2012.01.008",

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Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region. / Debourgogne, Anne; Hagen, Ferry; Elenga, Narcisse; Long, Laurence; Blanchet, Denis; Veron, Vincent; Lortholary, Olivier; Carme, Bernard; Aznar, Christine.

In: Revista Iberoamericana de Micologia, Vol. 29, No. 4, 01.03.2012, p. 210-3.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

TY - JOUR

T1 - Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region

AU - Debourgogne, Anne

AU - Hagen, Ferry

AU - Elenga, Narcisse

AU - Long, Laurence

AU - Blanchet, Denis

AU - Veron, Vincent

AU - Lortholary, Olivier

AU - Carme, Bernard

AU - Aznar, Christine

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.

AB - Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.

KW - Central Nervous System Fungal Infections/therapy

KW - Child, Preschool

KW - Cryptococcosis/therapy

KW - Cryptococcus gattii

KW - Female

KW - French Guiana

KW - Humans

KW - Remission Induction

U2 - 10.1016/j.riam.2012.01.008

DO - 10.1016/j.riam.2012.01.008

M3 - Article

C2 - 22366716

VL - 29

SP - 210

EP - 213

JO - Revista Iberoamericana de Micologia

JF - Revista Iberoamericana de Micologia

SN - 1130-1406

IS - 4

ER -

Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region

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Keywords

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