TY - JOUR
T1 - The adhesion G protein-coupled receptor GPR56/ADGRG1 in cytotoxic lymphocytes
AU - Hsiao, Cheng-Chih
AU - Vos, Els
AU - van Gisbergen, Klaas P J M
AU - Hamann, Jörg
N1 - This article is protected by copyright. All rights reserved.
PY - 2023/2/7
Y1 - 2023/2/7
N2 - GPR56/ADGRG1 is an adhesion G protein-coupled receptor connected to brain development, hematopoiesis, male fertility, and tumorigenesis. Nevertheless, expression of GPR56 is not restricted to developmental processes. Studies over the last years have demonstrated a marked presence of GPR56 in human cytotoxic NK and T cells. Expression of GPR56 in these cells is driven by the transcription factor HOBIT, corresponds with the production of cytolytic mediators and the presence of CX3 CR1 and CD57, indicates a state of terminal differentiation and cellular exhaustion, and disappears upon cellular activation. Functional studies indicate that GPR56 regulates cell migration and effector functions and thereby acts as an inhibitory immune checkpoint. We here discuss the current state of knowledge regarding GPR56 in cytotoxic lymphocytes.
AB - GPR56/ADGRG1 is an adhesion G protein-coupled receptor connected to brain development, hematopoiesis, male fertility, and tumorigenesis. Nevertheless, expression of GPR56 is not restricted to developmental processes. Studies over the last years have demonstrated a marked presence of GPR56 in human cytotoxic NK and T cells. Expression of GPR56 in these cells is driven by the transcription factor HOBIT, corresponds with the production of cytolytic mediators and the presence of CX3 CR1 and CD57, indicates a state of terminal differentiation and cellular exhaustion, and disappears upon cellular activation. Functional studies indicate that GPR56 regulates cell migration and effector functions and thereby acts as an inhibitory immune checkpoint. We here discuss the current state of knowledge regarding GPR56 in cytotoxic lymphocytes.
U2 - 10.1111/bcpt.13841
DO - 10.1111/bcpt.13841
M3 - Article
C2 - 36750420
SN - 1742-7835
VL - 133
SP - 286
EP - 294
JO - Basic & clinical pharmacology & toxicology
JF - Basic & clinical pharmacology & toxicology
ER -