TY - JOUR
T1 - The Caenorhabditis elegans Q neuroblasts
T2 - A powerful system to study cell migration at single-cell resolution in vivo
AU - Rella, Lorenzo
AU - Fernandes Póvoa, Euclides E
AU - Korswagen, Hendrik C
N1 - © 2016 Wiley Periodicals, Inc.
PY - 2016/4
Y1 - 2016/4
N2 - During development, cell migration plays a central role in the formation of tissues and organs. Understanding the molecular mechanisms that drive and control these migrations is a key challenge in developmental biology that will provide important insights into disease processes, including cancer cell metastasis. In this article, we discuss the Caenorhabditis elegans Q neuroblasts and their descendants as a tool to study cell migration at single-cell resolution in vivo. The highly stereotypical migration of these cells provides a powerful system to study the dynamic cytoskeletal processes that drive migration as well as the evolutionarily conserved signaling pathways (including different Wnt signaling cascades) that guide the cells along their specific trajectories. Here, we provide an overview of what is currently known about Q neuroblast migration and highlight the live-cell imaging, genome editing, and quantitative gene expression techniques that have been developed to study this process. genesis, 2016. © 2016 Wiley Periodicals, Inc. genesis 54:198-211, 2016. © 2016 Wiley Periodicals, Inc.
AB - During development, cell migration plays a central role in the formation of tissues and organs. Understanding the molecular mechanisms that drive and control these migrations is a key challenge in developmental biology that will provide important insights into disease processes, including cancer cell metastasis. In this article, we discuss the Caenorhabditis elegans Q neuroblasts and their descendants as a tool to study cell migration at single-cell resolution in vivo. The highly stereotypical migration of these cells provides a powerful system to study the dynamic cytoskeletal processes that drive migration as well as the evolutionarily conserved signaling pathways (including different Wnt signaling cascades) that guide the cells along their specific trajectories. Here, we provide an overview of what is currently known about Q neuroblast migration and highlight the live-cell imaging, genome editing, and quantitative gene expression techniques that have been developed to study this process. genesis, 2016. © 2016 Wiley Periodicals, Inc. genesis 54:198-211, 2016. © 2016 Wiley Periodicals, Inc.
U2 - 10.1002/dvg.22931
DO - 10.1002/dvg.22931
M3 - Article
C2 - 26934462
SN - 1526-954X
VL - 54
SP - 198
EP - 211
JO - Genesis
JF - Genesis
IS - 4
ER -