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The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity. / de Winter, F; Kwok, J C F; Fawcett, J W; Vo, T T; Carulli, D; Verhaagen, J.

In: Neural Plasticity, Vol. 2016, 2016, p. 3679545.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Harvard

de Winter, F, Kwok, JCF, Fawcett, JW, Vo, TT, Carulli, D & Verhaagen, J 2016, 'The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity' Neural Plasticity, vol. 2016, pp. 3679545. DOI: 10.1155/2016/3679545

APA

de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D., & Verhaagen, J. (2016). The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity. Neural Plasticity, 2016, 3679545. DOI: 10.1155/2016/3679545

Vancouver

de Winter F, Kwok JCF, Fawcett JW, Vo TT, Carulli D, Verhaagen J. The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity. Neural Plasticity. 2016;2016:3679545. Available from, DOI: 10.1155/2016/3679545

Author

de Winter, F ; Kwok, J C F ; Fawcett, J W ; Vo, T T ; Carulli, D ; Verhaagen, J. / The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity. In: Neural Plasticity. 2016 ; Vol. 2016. pp. 3679545

BibTeX

@article{6381bbd7db4143f68a61e812358c756e,
title = "The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity",
abstract = "During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain. The absence or presence of PNN strongly correlates with neuronal plasticity. It is not clear how PNN regulate plasticity. The repulsive axon guidance proteins Semaphorin (Sema) 3A and Sema3B are also prominently expressed in the postnatal and adult brain. In the neocortex, Sema3A accumulates in the PNN that form around parvalbumin positive inhibitory interneurons during the closure of critical periods. Sema3A interacts with high-affinity with chondroitin sulfate E, a component of PNN. The localization of Sema3A in PNN and its inhibitory effects on developing neurites are intriguing features and may clarify how PNN mediate structural neural plasticity. In the cerebellum, enhanced neuronal plasticity as a result of an enriched environment correlates with reduced Sema3A expression in PNN. Here, we first review the distribution of Sema3A and Sema3B expression in the rat brain and the biochemical interaction of Sema3A with PNN. Subsequently, we review what is known so far about functional correlates of changes in Sema3A expression in PNN. Finally, we propose a model of how Semaphorins in the PNN may influence local connectivity.",
author = "{de Winter}, F and Kwok, {J C F} and Fawcett, {J W} and Vo, {T T} and D Carulli and J Verhaagen",
year = "2016",
doi = "10.1155/2016/3679545",
language = "English",
volume = "2016",
pages = "3679545",
journal = "Journal of Neural Transplantation and Plasticity",
issn = "0792-8483",
publisher = "Walter De Gruyter",

}

RIS

TY - JOUR

T1 - The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

AU - de Winter,F

AU - Kwok,J C F

AU - Fawcett,J W

AU - Vo,T T

AU - Carulli,D

AU - Verhaagen,J

PY - 2016

Y1 - 2016

N2 - During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain. The absence or presence of PNN strongly correlates with neuronal plasticity. It is not clear how PNN regulate plasticity. The repulsive axon guidance proteins Semaphorin (Sema) 3A and Sema3B are also prominently expressed in the postnatal and adult brain. In the neocortex, Sema3A accumulates in the PNN that form around parvalbumin positive inhibitory interneurons during the closure of critical periods. Sema3A interacts with high-affinity with chondroitin sulfate E, a component of PNN. The localization of Sema3A in PNN and its inhibitory effects on developing neurites are intriguing features and may clarify how PNN mediate structural neural plasticity. In the cerebellum, enhanced neuronal plasticity as a result of an enriched environment correlates with reduced Sema3A expression in PNN. Here, we first review the distribution of Sema3A and Sema3B expression in the rat brain and the biochemical interaction of Sema3A with PNN. Subsequently, we review what is known so far about functional correlates of changes in Sema3A expression in PNN. Finally, we propose a model of how Semaphorins in the PNN may influence local connectivity.

AB - During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain. The absence or presence of PNN strongly correlates with neuronal plasticity. It is not clear how PNN regulate plasticity. The repulsive axon guidance proteins Semaphorin (Sema) 3A and Sema3B are also prominently expressed in the postnatal and adult brain. In the neocortex, Sema3A accumulates in the PNN that form around parvalbumin positive inhibitory interneurons during the closure of critical periods. Sema3A interacts with high-affinity with chondroitin sulfate E, a component of PNN. The localization of Sema3A in PNN and its inhibitory effects on developing neurites are intriguing features and may clarify how PNN mediate structural neural plasticity. In the cerebellum, enhanced neuronal plasticity as a result of an enriched environment correlates with reduced Sema3A expression in PNN. Here, we first review the distribution of Sema3A and Sema3B expression in the rat brain and the biochemical interaction of Sema3A with PNN. Subsequently, we review what is known so far about functional correlates of changes in Sema3A expression in PNN. Finally, we propose a model of how Semaphorins in the PNN may influence local connectivity.

U2 - 10.1155/2016/3679545

DO - 10.1155/2016/3679545

M3 - Article

VL - 2016

SP - 3679545

JO - Journal of Neural Transplantation and Plasticity

T2 - Journal of Neural Transplantation and Plasticity

JF - Journal of Neural Transplantation and Plasticity

SN - 0792-8483

ER -

ID: 2105002