The diverse functions of microRNAs in animal development and disease.

TY - JOUR

T1 - The diverse functions of microRNAs in animal development and disease.

AU - Kloosterman, W.P.

AU - Plasterk, R.H.A.

N1 - Reporting year: 2006

PY - 2006

Y1 - 2006

N2 - MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been implicated in tissue morphogenesis, cellular processes like apoptosis, and major signaling pathways. Emerging evidence suggests a direct link between miRNAs and disease, and miRNA expression signatures are associated with various types of cancer. In addition, the gain and loss of miRNA target sites appears to be causal to some genetic disorders. Here, we discuss the current literature on the role of miRNAs in animal development and disease.

AB - MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been implicated in tissue morphogenesis, cellular processes like apoptosis, and major signaling pathways. Emerging evidence suggests a direct link between miRNAs and disease, and miRNA expression signatures are associated with various types of cancer. In addition, the gain and loss of miRNA target sites appears to be causal to some genetic disorders. Here, we discuss the current literature on the role of miRNAs in animal development and disease.

U2 - 10.1016/j.devcel.2006.09.009

DO - 10.1016/j.devcel.2006.09.009

M3 - Article

SN - 1534-5807

VL - 11

SP - 441

EP - 450

JO - Developmental Cell

JF - Developmental Cell

IS - 4

ER -