The emerging role of retromer in neuroprotection

Kirsty J McMillan, Hendrick C Korswagen, Peter J Cullen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.

Original languageEnglish
Pages (from-to)72-82
Number of pages11
JournalCurrent Opinion in Immunology
Volume47
DOIs
Publication statusPublished - Aug 2017

Keywords

  • Animals
  • Cell-Matrix Junctions
  • Endosomal Sorting Complexes Required for Transport
  • Eukaryotic Cells
  • Humans
  • Neuroprotection
  • Parkinson Disease
  • Protein Transport
  • Proteolysis
  • Journal Article
  • Review

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