Abstract
Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.
| Original language | English |
|---|---|
| Pages (from-to) | 72-82 |
| Number of pages | 11 |
| Journal | Current Opinion in Immunology |
| Volume | 47 |
| DOIs | |
| Publication status | Published - Aug 2017 |
Keywords
- Animals
- Cell-Matrix Junctions
- Endosomal Sorting Complexes Required for Transport
- Eukaryotic Cells
- Humans
- Neuroprotection
- Parkinson Disease
- Protein Transport
- Proteolysis
- Journal Article
- Review