The emerging role of retromer in neuroprotection

Kirsty J McMillan; Hendrick C Korswagen; Peter J Cullen

doi:10.1016/j.ceb.2017.02.004

The emerging role of retromer in neuroprotection

Kirsty J McMillan
, Hendrick C Korswagen
, Peter J Cullen

Hubrecht Institute

School of Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD, UK.
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Cancer Genomics.nl and University Medical Center Utrecht, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands.
School of Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD, UK. Electronic address: [email protected].

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

51 Citations (Scopus)

Abstract

Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.

Original language	English
Pages (from-to)	72-82
Number of pages	11
Journal	Current Opinion in Immunology
Volume	47
DOIs	https://doi.org/10.1016/j.ceb.2017.02.004
Publication status	Published - Aug 2017

Keywords

Animals
Cell-Matrix Junctions
Endosomal Sorting Complexes Required for Transport
Eukaryotic Cells
Humans
Neuroprotection
Parkinson Disease
Protein Transport
Proteolysis
Journal Article
Review

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10.1016/j.ceb.2017.02.004

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abstract = "Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.",

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AU - Korswagen, Hendrick C

AU - Cullen, Peter J

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AB - Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.

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KW - Cell-Matrix Junctions

KW - Endosomal Sorting Complexes Required for Transport

KW - Eukaryotic Cells

KW - Humans

KW - Neuroprotection

KW - Parkinson Disease

KW - Protein Transport

KW - Proteolysis

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DO - 10.1016/j.ceb.2017.02.004

M3 - Article

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VL - 47

SP - 72

EP - 82

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -

The emerging role of retromer in neuroprotection

Abstract

Keywords

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